Biochemical Changes and Liver Tissue Pathology in Weanling Wistar Albino Rats with Protein-Energy Malnutrition

September 2003 in “ PubMed ”

Maisie Henrietta Etukudo, Oluyemi E. Agbedana, Edidiong Nnamso Akang, B. L. A. Osifo

hair loss kwashiorkor protein-energy malnutrition hypoalbuminaemia free radicals plasma retinol alanine aminotransferase aspartate aminotransferase PEM ALT AST

TLDR Low protein diets cause severe health issues in rats, but high protein diets can reverse these effects.

The study investigated the biochemical changes and liver tissue pathology in 64 weanling male Wistar albino rats with protein-energy malnutrition (PEM). The rats were divided into groups receiving high protein chow, high protein maize starch, and low protein maize starch diets. After 4 weeks, the low protein group exhibited growth failure, hair loss, oedema, fatty liver, metabolic acidosis, hypoalbuminaemia, and anaemia, which are characteristic of human kwashiorkor. These symptoms were reversed by switching to a high protein diet. The study suggested that reduced plasma retinol, increased plasma alanine and aspartate aminotransferases, and fatty liver in the low protein group indicated a significant role for free radicals in the aetiopathogenesis of kwashiorkor.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community How does hair loss and recovery work?

in Chat 12 upvotes 1 month ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Hair loss products whilst trying to conceive

in Minoxidil 1 upvotes 1 month ago

The conversation is about the safety of using hair loss products like Minoxidil and finasteride while trying to conceive and after birth. The user is seeking advice on whether these products are safe for the baby and if any men in similar situations can share their experiences.

community Hair loss treatment tier list by Dr Oscar Muñoz

in Treatment 908 upvotes 2 months ago

Dr. Oscar Muñoz's hair loss treatment tier list suggests oral minoxidil and finasteride are highly effective, while topical treatments like RU58841 and microneedling are less effective. Users discuss the effectiveness of various treatments, with some favoring oral options for their practicality and higher response rates.

community Hair Loss transformation Min/Fin/DermaStamp Age 23 M.

in Progress Pictures 127 upvotes 2 months ago

A user shared their hair loss transformation using Minoxidil, Finasteride, and DermaStamp, showing significant improvement over time. They noted quitting DermaStamp due to laziness and attributed past poor results to heavy smoking.

community Best hair loss treatment to get your hair back!

in Progress Pictures 3 months ago

Hair loss treatments include Minoxidil, Finasteride, hair transplant surgery, PRP therapy, laser therapy, natural remedies, and lifestyle changes. Combining treatments often yields the best results.

community Hair Loss Associated with Escitalopram (anti-depressant). Do SSRIs Affect the Hair Follicle?

in Research/Science 7 upvotes 3 months ago

A 22-year-old male experienced hair loss potentially linked to escitalopram, which stopped after switching to vortioxetine. His depressive symptoms improved with continued treatment.

Related Research

1 / 1 results

research Biochemical Changes and Liver Tissue Pathology in Weanling Wistar Albino Rats with Protein-Energy Malnutrition

4 citations, September 2003 in “PubMed”

Low protein diets cause severe health issues in rats, but high protein diets can reverse these effects.