research Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance
Understanding phenotypic plasticity is crucial for developing effective cancer therapies.
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300-330 / 1000+ results research OR2AT4 Activation by a Synthetic Odorant Stimulates Dermcidin Production in Human Hair Follicle Epithelium and Increases Follicular Resistance to Bacterial Contamination: A Novel Antimicrobial Folliculitis Therapy?
A synthetic sandalwood odorant can boost antimicrobial production in hair follicles, making them more resistant to bacteria.
research Resistance Training Improves Finasteride-Induced Protein Homeostasis Disruption in Rat Skeletal Muscle
Resistance exercise helps improve muscle protein balance disrupted by finasteride.
research Evaluation of Curl Durability for Artificial Hair Fibers
New resin B makes artificial hair fibers hold curls longer than traditional resin A.
research Polycystic Ovary Syndrome: Clinical and Biochemical Features
PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.
research Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update
The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
research The Pathophysiology of Polycystic Ovary Syndrome
Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
research Acne
Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.
research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome
Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
research Lifestyle Changes in Women with Polycystic Ovary Syndrome
Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.
research Endothelial Dysfunction in PCOS: Role of Obesity and Adipose Hormones
Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.
research Global Adiposity Rather Than Abnormal Regional Fat Distribution Characterizes Women with Polycystic Ovary Syndrome
Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.
research Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome
People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.
research Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene
A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.
research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome
Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.
research Clinical, Metabolic, and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, and Placebo-Controlled Trial
Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
research Polycystic Ovary Syndrome and Insulin-Resistant Hyperinsulinemia
Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
research Improvement of Endothelial Function with Metformin and Rosiglitazone Treatment in Women with Polycystic Ovary Syndrome
Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.
research Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome
Women with PCOS often have more body hair, acne, and skin darkening, and these signs are linked to metabolic issues like insulin resistance and high cholesterol.
research Tissue Insulin Sensitivity and Body Weight in Polycystic Ovary Syndrome
Lean and obese women with PCOS have similar levels of insulin resistance, indicating it's a core aspect of the condition.
research Prevalence of Hyperandrogenic States in Late Adolescent and Young Women: Epidemiological Survey on Italian High-School Students
Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.
research Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review
Polycystic Ovary Syndrome (PCOS) is common in women with conditions like anovulation, hirsutism, hair loss, and type 2 diabetes, and it can lead to health risks like heart disease, obesity, insulin resistance, and depression. Non-Classic Congenital Adrenal Hyperplasia (NC-CAH) is also discussed.
research Metabolic Aspects of Different Phenotypes of Polycystic Ovary Syndrome: Iranian PCOS Prevalence Study
The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.
research Acanthosis Nigricans and the Metabolic Syndrome
Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.
research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study
High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.
research History of Discovery of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.
research Clinical Case Seminar: Postmenopausal Androgen Excess - Challenges in Diagnostic Work-Up and Management of Ovarian Thecosis
The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.
research 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.
research Current Recommendations for the Diagnostic Evaluation and Follow-Up of Patients Presenting with Symptomatic Polycystic Ovary Syndrome
The diagnosis of polycystic ovary syndrome (PCOS) requires a detailed patient history, ultrasound scanning, hormone level checks, and assessments of ovulation, obesity, and insulin resistance. It's a variable condition that needs individualized management and is a significant risk factor for type 2 diabetes.
research Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Visceral and Subcutaneous Adipose Tissues of Patients with Polycystic Ovary Syndrome Is Associated with Adiposity
Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.