Combination of Metformin With Liraglutide in Treating HAIR-AN Syndrome in Children: A Case Report and Literature Review
December 2023
in “
PubMed
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metformin liraglutide Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans syndrome HAIR-AN syndrome hyperandrogenism insulin resistance acanthosis nigricans acne hirsutism irregular menstruation androgen excess obesity hyperglycemia menstrual disorder Glucophage Victoza HAIR-AN androgen excess symptoms
TLDR Metformin and liraglutide improved symptoms of HAIR-AN syndrome in a child.
The document discusses a case of a child with Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans (HAIR-AN) syndrome, a rare subtype of polycystic ovarian syndrome. The syndrome can lead to hyperandrogenism, insulin resistance, and acanthosis nigricans, along with symptoms like acne, hirutism, irregular menstruation, and other androgen excess symptoms. The child, who was admitted to the Department of Endocrinology, China-Japan Friendship Hospital, showed significant improvement in obesity, insulin resistance, hyperglycemia, menstrual disorder, and acanthosis nigricans after being treated with metformin and liraglutide. The document concludes that early diagnosis and symptomatic supportive treatment can improve the quality of life in patients with HAIR-AN syndrome.
