Nonalcoholic Fatty Liver Disease in Young Adult Egyptian Women with Polycystic Ovary Syndrome

    January 2013 in “ Egyptian Liver Journal ”
    Abd-Elmohesen E. Eldesoky, Yahia Z. Gad, Nancy M. Ahmed
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    TLDR Many young Egyptian women with PCOS also have fatty liver disease, especially if they are overweight and insulin resistant.
    The study from 2013 investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) in 63 young adult Egyptian women with polycystic ovary syndrome (PCOS), finding a significant association between the two conditions. It was observed that 60.8% of overweight-obese women with PCOS had insulin resistance (IR) and 52.17% had NAFLD, while among lean patients, 18.2% had IR and 17.6% had NAFLD. Factors such as homeostasis model assessment of insulin resistance (HOMA-IR), fasting glucose, and total cholesterol were identified as predictive for NAFLD development. The study highlighted the need for clinicians to be vigilant for liver disease in PCOS patients, particularly those with high BMI, fasting insulin, HOMA-IR levels, and elevated alanine aminotransferase (ALT), which could indicate a higher risk of nonalcoholic steatohepatitis (NASH). Early recognition and intervention were emphasized for better outcomes.
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