205 citations,
August 2007 in “Experimental Cell Research” Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.
249 citations,
November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
27 citations,
March 2018 in “Biomaterials” Three specific proteins can turn adult skin cells into hair-growing cells, suggesting a new hair loss treatment.
1 citations,
December 2010 in “Elsevier eBooks” Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.
69 citations,
February 2008 in “The American journal of pathology” Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.
117 citations,
April 2008 in “Developmental biology” Ectodysplasin inhibits Wnt signaling to help form hair follicles.
3 citations,
October 2023 in “Military Medical Research/Military medical research” Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.
April 2024 in “Military Medical Research/Military medical research” Cellular and immunotherapies show promise for healing chronic wounds but need more research.
96 citations,
December 2018 in “Immunity” Targeting TGFβ can improve skin immunity in older people.
35 citations,
December 2020 in “International Journal of Molecular Sciences” Mast cells likely promote skin scarring and fibrosis, but their exact role is still unclear.
6 citations,
August 2007 in “Journal of Surgical Research” Mice genetically modified to produce more Del1 protein had faster hair regrowth.
5 citations,
February 2022 in “International Journal of Molecular Sciences” Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.
5 citations,
September 2013 in “BMB Reports” BMPR1a-ECD reduces wrinkles much more effectively than retinoic acid.
85 citations,
January 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
46 citations,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
70 citations,
April 2017 in “Lasers in surgery and medicine” Blue light promotes hair growth by interacting with specific receptors in hair follicles.
33 citations,
December 2004 in “Differentiation” Mouse amnion can turn into skin and hair follicles with help from certain cells and factors.
2 citations,
October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
47 citations,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Premature graying of hair may suggest health issues and currently lacks effective treatments.
54 citations,
January 2023 in “Signal Transduction and Targeted Therapy” New therapies are being developed that target integrin pathways to treat various diseases.
18 citations,
April 2016 in “The journal of immunology/The Journal of immunology” Thymic mesenchymal cells have unique gene expression that supports their specific functions in the thymus.
January 2023 in “Theranostics” Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.
19 citations,
October 1994 in “Tumori Journal” As of 1994, treatments for liver cancer had not significantly improved patient survival.
June 2024 in “Synthetic and systems biotechnology” A fragment of human type XVII collagen shows great potential for skin health and wound healing.
39 citations,
December 2001 in “JNCI: Journal of the National Cancer Institute” Using a gene therapy with the Sonic Hedgehog gene helps mice regrow hair faster after losing it from chemotherapy.
5 citations,
January 2023 in “Cell proliferation” Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.
55 citations,
April 2010 in “Cancer and Metastasis Reviews” TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
76 citations,
March 2005 in “Journal of Molecular Medicine” Certain mice without specific receptors or mast cells don't lose hair from stress.
54 citations,
August 2005 in “Alcohol” Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.
38 citations,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.