A Comparative Study of Different Treatment Modalities of Polycystic Ovarian Syndrome in Women of Reproductive Age Group at Tertiary Care Centre

August 2023 in “ International journal of reproduction, contraception, obstetrics and gynecology ”

Arvindar, Sangeeta Sen

letrozole metformin oral contraceptive pills OCP hirsutism acne menstrual regularity polycystic ovarian syndrome PCOS birth control pills

TLDR Combining letrozole with metformin is the most effective treatment for inducing pregnancy in women with PCOS.

The study compared different treatments for polycystic ovarian syndrome (PCOS) in 290 women over one year. Results showed that combining letrozole with metformin led to a significantly higher pregnancy rate (23 women) compared to letrozole alone (9 women). Metformin combined with lifestyle modification resulted in better weight reduction than lifestyle changes alone or combined with oral contraceptive pills (OCP). OCP and OCP with metformin significantly reduced hirsutism and acne. Menstrual regularity was best achieved with the combination of OCP and metformin. Overall, the combination of letrozole and metformin was superior for inducing pregnancy compared to letrozole alone.

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research Metformin Therapy for the Reproductive and Metabolic Consequences of Polycystic Ovary Syndrome

50 citations, August 2017 in “Diabetologia”

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

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200 citations, October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.