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Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

Vitamin D and calcium are important for skin stem cell function and wound healing.

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

Sulforaphane from broccoli may help treat certain cancers, hormone issues, and hair loss.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Scientists found cells in hair that are key for growth and color.

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Only skin melanocytes, not other types, can color hair in mice.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

Natural skincare products may help reduce sun damage and support the skin's daily cycle.

Human umbilical cord stem cell vesicles may help treat aging and related diseases.

Certain natural products may help stimulate hair growth by affecting stem cell activity in the scalp.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

Wnt5a may contribute to psoriasis by reducing skin cell growth, blocking skin cell maturation, and increasing inflammation.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

Plant sterols have health benefits like lowering cholesterol, but more research is needed to understand their effects and improve their extraction and sustainability.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Mesenchymal stem cells show promise for effective skin repair and regeneration.

Accurate diagnosis of cicatricial alopecias requires thorough scalp examination and multiple biopsy techniques.