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This study found that TSG-enriched Polygonum multiflorum extract, optimized through microwave-assisted and chromatographic methods, promotes hair regrowth in a mouse model of androgenetic alopecia via 5α-reductase inhibition and Wnt/β-catenin pathway activation, suggesting its potential as a natural treatment.

This review discusses the drug treatment of benign prostatic syndrome, highlighting the efficacy of combination therapies over monotherapies in patients at high risk for disease progression, but notes increased side effects and costs.

In a cell-free test setting, this study found that a novel saw palmetto extract effectively inhibited the 5α-reductase type II enzyme, showing promising bioactivity comparable to finasteride for promoting prostate health.

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

This study explored using 3D models derived from reflectance confocal microscopy to better understand and differentiate melanoma on sun-damaged skin, suggesting enhanced diagnostic possibilities.

This review discusses how the HSD3B1(1245C) genotype may impact androgen physiology and the progression of castration-resistant prostate cancer, and does not report new experimental results.

This study found that the novel IPC analog SIG-1451 may inhibit inflammatory cytokine release in cell-based assays relevant to allergic dermatitis.

This study evaluates finasteride's safety and efficacy for treating male chronic pelvic pain syndrome, but the abstract does not report any results.

In this study, researchers found that people with Parkinson's disease showed higher levels of inflammasome proteins, including caspase-1, ASC, and IL-18, compared to healthy individuals, suggesting these proteins as reliable biomarkers for inflammation in PD.

This study reports that 5-alpha-reductase inhibitors do not prevent prostate cancer and merely reduce the likelihood of undergoing diagnostic biopsies, potentially misleading patients and physicians.

This study found that Finasteride at doses of 5 mg or higher may reduce the expression of key spermatogenesis biomarkers, potentially impacting male fertility in mice.

This study found that metformin, insulin, and ACE inhibitors were associated with lower PSA levels, but statins did not decrease PSA, whereas low dose finasteride (1 mg) reduced PSA levels similarly to the higher 5 mg dose.

This case study details a 44-year-old woman with rheumatoid arthritis and systemic lupus erythematosus who developed hypereosinophilic asthma and was initially treated as ANCA-negative eosinophilic granulomatosis with polyangiitis. Her condition, eventually classified as HASM, underscores the need for evaluating EGPA-spectrum disorders in similar scenarios.

This study examined serum PSA levels in women with androgenetic alopecia to evaluate their potential as a marker for androgen effects on target organs.

Large prostate patients more likely to have hair loss.

This study reports that the transgenic expression of Dsg1 in mice rescued the severe B6-Dsg3−/− phenotype and created a syngeneic mouse model of pemphigus vulgaris, which may aid in understanding autoimmunity mechanisms.

This study found that administering human amniotic mesenchymal stem cells (hAMSCs) in a mouse model of psoriasis improved skin lesions and reduced inflammation-related markers, suggesting potential therapeutic benefit and safety for treating psoriasis, and identified specific gene targets involved in the treatment's mechanism.

This study found that immune-mediated destruction of bulge stem cells is a key factor in the alopecia observed in AE mice, suggesting it as a model for studying primary cicatricial alopecias, particularly lichen planopilaris.

In this study, the researchers explored how the loss of structural integrity in hair follicles due to reduced α-SMA expression in the vertex area may contribute to androgenetic alopecia.

This study found that overexpression of Gsdma3 in mice led to epidermal hyperplasia, skin inflammation, and hair growth defects, suggesting gain-of-function mutations in Gsdma3 cause these conditions.

This study demonstrated that methylation of the 5-alpha reductase type 2 (5-AR2) promoter is linked to reduced expression of the 5-AR2 protein, possibly explaining resistance to Finasteride in some BPH patients.

This study found that high doses of cyproterone acetate were associated with an increased risk of meningioma, especially with exposure longer than one year.

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

This study explored using large language models to automatically identify monkeypox cases from electronic medical records, finding that models based on DeepSeek features performed better than traditional methods, with logistic regression showing high accuracy in detecting key symptoms like fever and rash.

In this study, low concentrations of DMSO were found to decrease androgen receptor expression and inhibit the migration of prostate cancer cells, suggesting potential as an anticancer therapy.

This study found that women with polycystic ovary syndrome had significantly higher levels of prostate-specific antigen, which positively correlated with testosterone levels, the LH/FSH ratio, and hirsutism severity.

This case report describes a patient who developed multiple skin reactions, including eczematous lesions and alopecia areata, during adalimumab treatment, but found no improvement in pustulosis palmoplantaris with different biologics.

This study found that after 12 weeks of taking the trial product SHPro®, participants reported improvements in prostate symptom scores and erectile function, with confirmed safety.

Finasteride may reduce prostate cancer risk.