Serum Prostate Specific Antigen Level in Women with Polycystic Ovary Syndrome

July 2016 in “ Mağallaẗ Kulliyyaẗ al-ṭibb Baġdād ”

Wasan Wajdi Ibrahim, Raya Kh. Salah, Widad M. Abbas

Polycystic Ovary Syndrome PCOS prostate-specific antigen PSA hyperandrogenism Ferriman-Gallway Score FGS LH/FSH ratio serum testosterone hirsutism testosterone

TLDR Women with PCOS have higher PSA levels, which are linked to increased male hormone levels and hirsutism.

The study conducted by Wasan W. Ibrahim, Raya Kh. Salah, and Widad M. Abbas in 2016 involved 100 women, 50 of whom had Polycystic Ovary Syndrome (PCOS) and 50 who were healthy controls. The researchers measured the level of prostate-specific antigen (PSA) in these women to evaluate its value as a marker of hyperandrogenism in women with PCOS. The results showed that the mean serum PSA level was significantly higher in women with PCOS compared to the control group (0.15+0.09 vs. 0.016+0.003). There was a significant positive correlation between serum PSA level and Ferriman-Gallway Score (FGS), LH/FSH ratio, and serum testosterone with r values of 0.964, 0.988, and 0.922 respectively. The study concluded that PSA level is significantly higher in women with PCOS and correlates positively with LH/FSH, testosterone, and FGS. Furthermore, a higher score of hirsutism correlated with a higher serum PSA level.