Concomitant Occurrence of Acneiform Eruption, Alopecia Areata, and Urticaria During Adalimumab Treatment in a Patient With Pustulosis Palmoplantaris: Case Report and Literature Review
October 2011
in “
Dermatologica Sinica
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary This case report describes a patient who developed multiple skin reactions, including eczematous lesions and alopecia areata, during adalimumab treatment, but found no improvement in pustulosis palmoplantaris with different biologics.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 50-year-old male with pustulosis palmoplantaris (PPP) developed acneiform eruptions, alopecia areata (AA), and urticaria after starting adalimumab treatment. Despite switching to etanercept and other medications, his PPP persisted, though the adverse skin reactions gradually improved. The case highlighted the rare occurrence of these cutaneous reactions with adalimumab, suggesting a possible link to immune dysregulation. The patient eventually achieved remission from PPP after quitting smoking and continuing acitretin. This case underscored the complexity of managing PPP and the potential for significant adverse reactions with TNF-α inhibitors.
