Eosinophils in Fibrous Tracts and Near Hair Bulbs: A Helpful Diagnostic Feature of Alopecia Areata

February 2000 in “ Journal of the American Academy of Dermatology ”

Mohammad El Darouti, Salonas A. Marzouk, Eman Sharawi

TLDR Eosinophils are not a reliable marker for diagnosing alopecia areata.

A study re-examined 51 slides of alopecia areata (AA) lesions to verify the presence of eosinophils, previously suggested as a diagnostic feature by Elston et al. Eosinophils were found in only 11 of the 51 slides, indicating their presence was too infrequent to be a reliable diagnostic marker. In contrast, mast cells were detected in 48 of the slides, suggesting they might be a more consistent feature of AA. However, further research was needed to determine if mast cells could serve as a diagnostic clue, as their presence in AA simulators had not been thoroughly investigated.

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Research cited in this study

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research Eosinophils in Fibrous Tracts and Near Hair Bulbs: A Helpful Diagnostic Feature of Alopecia Areata

64 citations , July 1997 in “Journal of The American Academy of Dermatology”

Finding eosinophils near hair bulbs helps diagnose alopecia areata.

research Histopathology of Non-Scarring Alopecia

122 citations , April 1995 in “Journal of Cutaneous Pathology”

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research Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis

78 citations , July 1984 in “Journal of Investigative Dermatology”

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