Editorial Comment 1

September 2004 in “ Urology ”

Ian M. Thompson, Catherine M. Tangen

finasteride 5-alpha-reductase prostate cancer BPH PSA Propecia benign prostatic hyperplasia prostate-specific antigen

TLDR Finasteride may reduce prostate cancer risk.

The document discussed the findings of a study that extended observations from the Prostate Cancer Prevention Trial (PCPT) regarding the use of finasteride to reduce prostate cancer risk. This study differed from the PCPT in several ways: it had a smaller sample size, was a retrospective analysis, lacked central pathology review, used a different agent inhibiting both isoforms of 5-alpha-reductase, and involved participants with generally higher PSA values and clinical symptoms of BPH. Despite these differences, like the PCPT, participants underwent annual examinations with digital rectal exams and PSA measurements.

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