Amelioration of Psoriasis-Like Skin Lesions by Human Amniotic Mesenchymal Stem Cells: Insights from Multiomics Profiling in Mice

    February 2026 in “ Frontiers in Immunology ”
    Liehao Yang, Baihui Miao, Qian Sun, Fangqing Zhang, Hongyan Sun, Zilong Zhou, Yue Hu, Zhiming Cui, D. Y. Wang, Chenlu Liu, Liang Zhang, Qianying Hu, Xianling Cong
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    Studysummary This study found that administering human amniotic mesenchymal stem cells (hAMSCs) in a mouse model of psoriasis improved skin lesions and reduced inflammation-related markers, suggesting potential therapeutic benefit and safety for treating psoriasis, and identified specific gene targets involved in the treatment's mechanism.
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    The study demonstrates that human amniotic mesenchymal stem cells (hAMSCs) are effective and safe for treating psoriasis-like skin lesions in mice. Through multiomics profiling, the research provides insights into the mechanisms by which hAMSCs exert their therapeutic effects, confirming their potential as a treatment option for psoriasis.
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