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    Glossary Prolactin

    hormone from the pituitary gland that stimulates milk production

    Prolactin, also known as PRL or luteotropic hormone, is a hormone produced by the pituitary gland. It plays a crucial role in lactation by stimulating milk production in mammals. Additionally, prolactin has over 300 functions in the body, including roles in metabolism, immune system regulation, and development of the reproductive system. Elevated levels of prolactin can lead to conditions such as hyperprolactinemia, which can affect menstrual cycles and fertility.

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    1. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006 · 128 citations
    2. Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone Journal of Investigative Dermatology · 2008 · 98 citations
    3. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003 · 91 citations
    4. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice* Endocrinology · 2001 · 73 citations
    5. Prolactin—a novel neuroendocrine regulator of human keratin expression<i>in situ</i> The FASEB Journal · 2010 · 64 citations
    6. The role of prolactin in the reactivation of hair follicles in relation to moulting in cashmere goats 1994 · 62 citations
    7. Growth of secondary hair follicles of the Cashmere goat in vitro and their response to prolactin and melatonin. PubMed · 1994 · 56 citations
    8. Prolactin delays hair regrowth in mice Journal of Endocrinology · 2006 · 53 citations
    9. Prolactin: an emerging force along the cutaneous–endocrine axis Trends in Endocrinology and Metabolism · 2010 · 51 citations
    10. Effect of constant-release melatonin implants and prolonged exposure to a long day photoperiod on prolactin secretion and hair growth in mouflon (Ovis gmelini musimon) Domestic animal endocrinology · 2004 · 51 citations
    11. Effects of maintaining solstice light and temperature on reproductive activity, coat growth, plasma prolactin and melatonin in goats Reproduction · 1999 · 47 citations
    12. Does prolactin play a role in skin biology and pathology? Medical hypotheses · 1991 · 41 citations
    13. The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications Expert Opinion on Therapeutic Targets · 2015 · 38 citations
    14. Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles <i>in vitro</i> British Journal of Dermatology · 2010 · 37 citations
    15. Mind the (Gender) Gap: Does Prolactin Exert Gender and/or Site-Specific Effects on the Human Hair Follicle? Journal of Investigative Dermatology · 2009 · 36 citations
    16. Prolactin as a candidate sebotrop(h)ic hormone? Experimental Dermatology · 2018 · 26 citations
    17. Identification of Differentially Expressed Genes During a Wool Follicle Growth Cycle Induced by Prolactin Journal of Investigative Dermatology · 1999 · 26 citations
    18. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    19. Serum prolactin and dehydroepiandrosterone concentrations during the summer and winter hair growth cycles of mink (Mustela vison) Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 1998 · 18 citations
    20. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001 · 14 citations
    21. A Neutralizing Prolactin Receptor Antibody Whose In Vivo Application Mimics the Phenotype of Female Prolactin Receptor-Deficient Mice Endocrinology · 2015 · 14 citations
    22. Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans 2012 · 12 citations
    23. Role of prolactin in regulating the onset of winter fur growth in mink (Mustela vison): A reconsideration 1999 · 12 citations
    24. Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats 2021 · 7 citations
    25. What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review Reviews in Endocrine and Metabolic Disorders · 2024 · 6 citations
    26. Responses of prolactin and hair growth to selection for age at puberty in Angus cattle Animal · 2010 · 6 citations
    27. Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology International Journal of Molecular Sciences · 2024 · 3 citations
    28. Neues aus der Haarforschung: Einfluss von Prolaktin, Retinoiden und Transforming Growth Factor-β auf das Haarwachstum Aktuelle Dermatologie · 2005 · 3 citations
    29. Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women Reproductive Sciences · 2018 · 3 citations
    30. Correlation between MRI findings of pituitary gland and prolactin level among hyperprolactinemia adult female Saudi patients in rural areas: A retrospective multicentric study Medicine · 2025 · 2 citations