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Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

New effective scar treatments are urgently needed due to the current options' limited success.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Latanoprost can make eyelashes longer, thicker, and darker.

Blocking JAK-STAT signaling can lead to hair growth.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Aging causes skin stem cells to work less effectively.

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Blocking β-catenin in skin cells improves hair growth during wound healing.

Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.