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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Niosomes improve minoxidil skin delivery for hair loss treatment.

Apoptosis is essential for human skin development and forming a functional epidermis.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Fat cells help recruit healing cells and build skin structure during wound healing.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Noggin is necessary to start the hair growth phase in skin after birth.

New effective scar treatments are urgently needed due to the current options' limited success.

Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Improving skin barrier and using antifungal treatments can help manage dandruff.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.