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Glossary Preclinical Studies

laboratory and animal tests before human clinical trials

Preclinical Studies, also known as Preclinical Research or Preclinical Testing, are a phase of research conducted before clinical trials in humans. These studies involve laboratory experiments and animal testing to evaluate the safety, efficacy, and biological activity of a new drug or treatment. The goal is to gather enough data to determine whether the treatment is safe and promising enough to move on to human trials.

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research Preclinical studies of a novel polyherbal phyto–complex hair growth promoting cream

16 citations , January 2012 in “Asian pacific Journal of Tropical Biomedicine”

This study found that a 2% polyherbal phyto-complex cream containing aqueous extracts of Trichosanthes cucumerina and Abrus precatorius effectively promoted hair growth in preclinical tests, comparable to minoxidil 2%.

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health

research Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health

11 citations , January 2017 in “Evidence-based Complementary and Alternative Medicine”

This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).

research The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines

11 citations , December 2024 in “Wound Repair and Regeneration”

In this study, researchers created the WRAHPS Guidelines to standardize the reporting of preclinical wound healing studies, aiming to improve transparency, enable comparative analysis, and support the development of human clinical trials for wound healing disorders.

research Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

30 citations , February 2022 in “Stem Cell Reviews and Reports”

This review of stem cell-based tissue engineering treatments in preclinical burn wound models reports promising improvements in skin repair, suggesting potential as an enhanced therapy for burn wounds.

research Topically used herbal products for the treatment of hair loss: preclinical and clinical studies

25 citations , July 2017 in “Archives of Dermatological Research”

This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.

research The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies

11 citations , June 2018 in “Sexual medicine reviews”

This review evaluates existing preclinical and clinical studies on stromal vascular fraction for treating male sexual dysfunction, finding limited data and emphasizing the need for more research before conducting clinical trials.

research Therapeutic Effects of Alkaloids on Influenza: A Systematic Review and Meta-Analysis of Preclinical Studies

February 2025 in “International Journal of Molecular Sciences”

This meta-analysis of animal studies found that alkaloids have potential anti-influenza and anti-inflammatory effects, correlating with improved viral titers and survival rates, though they did not effectively reduce TNF-α and IL-6 levels. Extensive further studies are needed to confirm these findings before considering clinical application.

research Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies

16 citations , July 2025 in “Journal of Translational Medicine”

In this study, MSC-scaffold combinations were found to significantly enhance wound closure, collagen deposition, angiogenesis, and growth factor expression while modulating inflammatory responses in preclinical burn wound models, though significant heterogeneity limits immediate clinical application.

research Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

46 citations , April 2021 in “International Journal of Molecular Sciences”

This review discusses the potential of curcumin and its formulations to mitigate neuropathic and postoperative pain, highlighting positive outcomes in preclinical and clinical studies but noting the need for further clinical research.

research Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis

8 citations , June 2025 in “Stem Cell Research & Therapy”

This review discusses the potential of exosome therapy for treating diabetic peripheral neuropathy but highlights the need for more robust preclinical trials before clinical application.

research Exosome-driven treatments for hair regrowth in androgenetic alopecia: a systematic review of preclinical studies, clinical experiments, safety, and future prospects

June 2026 in “Molecular Biology Reports”

research Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

15 citations , July 2020 in “Stem Cell Research & Therapy”

This study found that stem cell therapy significantly improved burn healing rates in animal models, with hair follicle stem cells showing particularly strong effects.

Review on Methods and Mechanisms for Producing Polycystic Ovary Syndrome (PCOS) in Animal Models: Experimental Purpose (Pre-Clinical Studies)

research Review on methods and mechanisms available for producing poly cystic ovary syndrome (PCOS) in animal models: experimental purpose (pre-clinical studies)

January 2022 in “World journal of pharmaceutical sciences”

This review discusses methods for inducing polycystic ovary syndrome in animal models, with letrozole considered the easiest and most convenient for testing new treatments, but it reports no new clinical findings.

Quercetin-Based Advanced Delivery Systems: From Multimodal Nano-Theranostics to Microneedles - A Recent Update on Their Preclinical Studies

research Quercetin-Based Advanced Delivery Systems – From Multimodal Nano-theranostics to Microneedles: a Recent Update on Their Preclinical Studies

April 2026 in “International Journal of Nanomedicine”

This review explores quercetin's potential in multifunctional theranostic systems, highlighting its bioactivity and the challenges of improving its clinical application through innovative strategies like nanoencapsulation, while noting that research in this area is underdeveloped.

research 614 Humanized mouse model for hair follicle studies

September 2019 in “Journal of Investigative Dermatology”

This study established a model using nude mice to successfully graft human scalp skin, maintaining hair follicle growth and skin integrity for at least two months, which may aid preclinical research.

research Therapeutic Potential of Topical Metformin in Diabetic Wound Healing: Preclinical Mechanistic Insights

July 2026 in “Jurnal Kesehatan”

This review of preclinical studies suggests that topical metformin could aid diabetic wound healing via multiple pathways, but emphasizes the need for further clinical trials to confirm its safety and efficacy.

research Omega Fatty Acids in Hair Loss Disorders: A Scoping Review of Preclinical and Clinical Evidence

September 2026 in “Journal of Cosmetic Dermatology”

This scoping review reports that preclinical studies suggest omega fatty acids may promote hair follicle growth, but clinical evidence is mixed, with no support for their standalone use in treating alopecia.

research Unraveling Translational Insights into Systemic Multi-Organ Toxicity of Cytosine Arabinoside (Ara-C): A Systematic Review of Preclinical Animal Evidence

December 2025 in “Current Issues in Molecular Biology”

In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.

Synergistic Effects of Mesenchymal Stem Cell Secretome and Wnt10b on Hair Follicle Regeneration in a 3D Bioengineering Model: A Preclinical Study

research Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study

November 2025 in “Stem Cell Research & Therapy”

In this study, the authors reported that combining PMSC-secretome and Wnt10b in a GelMA hydrogel scaffold promoted effective hair follicle biofabrication and hair growth in a small in vivo experiment. They emphasized the need for larger studies to confirm these results.

research Pre-Clinical Cell-Based Therapy for Limbal Stem Cell Deficiency

28 citations , August 2015 in “Journal of functional biomaterials”

This review examines cell-based therapies for limbal stem cell deficiency, highlighting epidermal and hair follicle-derived stem cells as promising candidates for future clinical trials, but reports no new clinical findings.

research New developments in the molecular treatment of ichthyosis: review of the literature

21 citations , July 2022 in “Orphanet journal of rare diseases”

This review discusses recent advancements in therapies for ichthyosis, highlighting promising prospects in protein replacement and gene therapy, but it reports no new clinical results.

Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

research Imaging prostate cancer (PCa) with [^99m Tc(CO)₃ ]finasteride dithiocarbamate

4 citations , March 2018 in “Journal of labelled compounds & radiopharmaceuticals”

In this study, researchers developed a new prostate cancer imaging agent, a [99m Tc]tricarbonyl complex derived from finasteride, which demonstrated high radiochemical purity and significant uptake in the prostate of a rat model, suggesting its potential for noninvasive prostate cancer imaging.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.

research Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

12 citations , April 2022 in “Journal of cosmetic dermatology”

This review found that while preclinical studies highlight the potential benefits of exosome therapeutics for hair loss, clinical evidence on their safety and effectiveness for alopecia is currently lacking, requiring further research.

research ISID0197 - Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model

May 2023

This study describes a new method using ImageJ to quantitatively assess hair loss in mice with alopecia areata, offering a more precise and reproducible alternative to traditional visual scoring systems by employing image-based analysis techniques.

research Topical Melatonin for Treatment of Androgenetic Alopecia

39 citations , January 2012 in “International Journal of Trichology”

This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.

research The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin

1 citations , February 2024 in “Pharmaceutics”

This review highlights recent developments in nanovesicular carriers for enhancing molecule delivery into and across the skin, focusing on the design and evolution of phospholipid and non-phospholipid systems used in cosmetics and treating various skin conditions.

research Targeting the hallmarks of aging: preclinical evidence and molecular mechanisms underlying the therapeutic potential of Centella asiatica (L.) Urban

June 2026 in “Journal of Biological Studies”

This review synthesizes preclinical evidence suggesting that Centella asiatica may extend healthspan by modulating aging hallmarks, enhancing DNA repair, improving mitochondrial function, and reducing inflammation and oxidative stress, potentially paving the way for future gerotherapeutic strategies.

research Pre-clinical non-viral vectors exploited forin vivoCRISPR/Cas9 gene editing: an overview

23 citations , January 2022 in “Biomaterials Science”

Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

research Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects

22 citations , November 2020 in “Frontiers in Physics”

This review discusses the experimental strategies and technological challenges of proton minibeam radiotherapy (pMBRT) and reports no clinical results; it highlights the potential of using a 3 GHz linear accelerator for precision therapy research.