The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines

The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines aim to standardize the reporting of preclinical wound healing studies to enhance transparency, consistency, and reproducibility. Developed with the Wound Care Collaborative Community, these guidelines provide checklists and templates for reporting experimental conditions in animal and human ex vivo models. They address the variability and complexity of wound healing processes and the lack of existing standards, which hinder the translation of preclinical findings to clinical applications. The guidelines emphasize the importance of selecting appropriate animal models, considering biological variables, and using power analysis for sample sizes. They also discuss the impact of occlusive dressings, the variability in wound-induced hair neogenesis studies, and the advantages and limitations of various animal models, including rodents, pigs, rabbits, and human ex vivo models. Overall, WRAHPS seeks to improve the development of effective therapies for wound healing disorders and support regulatory compliance.