Cell-Derived Exosome Therapy for Diabetic Peripheral Neuropathy: A Preclinical Animal Studies Systematic Review and Meta-Analysis

This systematic review and meta-analysis of 11 preclinical animal studies explores the efficacy of cell-derived exosome therapy for diabetic peripheral neuropathy (DPN). The findings suggest that exosome therapy can significantly improve nerve conduction velocity, enhance small sensory nerve fiber regeneration, alleviate neuropathic pain, and improve vascular function, contributing to peripheral nerve repair and neurovascular remodeling. Despite promising results, challenges such as heterogeneity in exosome sources, administration routes, and outcome metrics, as well as methodological biases, complicate direct comparisons across studies. The review calls for standardized research designs and further clinical trials to validate the therapeutic potential of exosomes for DPN.