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    Glossary Polygonum multiflorum

    traditional Chinese herb, also known as Fo-Ti, used for hair health

    Polygonum multiflorum, commonly known as Fo-Ti or He Shou Wu, is a traditional Chinese medicinal herb reputed for its potential benefits in promoting hair growth and overall vitality. It is often used in herbal remedies to treat conditions like alopecia and is believed to restore hair color and strength, although scientific evidence supporting these claims is limited.

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    Research 30 of 574

    1. Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice Journal of Ethnopharmacology · 2011 · 91 citations
    2. Promotion effect of constituents from the root of Polygonum multiflorum on hair growth Bioorganic & Medicinal Chemistry Letters · 2013 · 51 citations
    3. Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells BMC complementary medicine and therapies · 2020 · 15 citations
    4. Integrated chemometric fingerprints of antioxidant activities and HPLC–DAD–CL for assessing the quality of the processed roots of Polygonum multiflorum Thunb. (Heshouwu) Chinese Medicine · 2016 · 12 citations
    5. Discrimination and Proper Use of Polygoni Multiflori Radix, Cynanchi Wilfordii Radix, and Cynanchi Auriculati Radix in Korea: A Descriptive Review Evidence-based Complementary and Alternative Medicine · 2015 · 7 citations
    6. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging International Journal of Molecular Sciences · 2025 · 3 citations
    7. Synergistic effects of Rhynchosia nulubilis and Polygonum multiflorum extract combination on cell proliferation via targeting IGFBP-1 & NT-3 and cytotoxicity suppression in testosterone-induced human dermal papilla cells PLoS ONE · 2025 · 2 citations
    8. Bioinspired engineering of Polygonum multiflorum root nanovesicles regulates dermal papilla cells in vitro and stimulates human hair follicle growth ex vivo Frontiers in Physiology · 2026
    9. Polygonum multiflorum in AGA: network to dynamics 2025
    10. Exploring the molecular mechanism of Polygonum multiflorum in treating androgenic alopecia based on the methods of bioinformatics and molecular docking Medicine · 2025
    11. He Shou Wu (Polygonum multiflorum)-Induced Hepatocellular Hepatitis ˜The œAmerican journal of gastroenterology · 2017
    12. Optimization and Characterization of TSG-Enriched Polygonum multiflorum Extract and Its Dual Mechanism Against Androgenetic Alopecia via 5α-Reductase Inhibition and Wnt/β-Catenin Activation International Journal of Molecular Sciences · 2026
    13. Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo Pharmacological Research · 2025
    14. Molecular mechanism of polygonum multiflorum in the treatment of androgenic alopecia: based on bioinformatics and molecular docking method DOAJ (DOAJ: Directory of Open Access Journals) · 2022
    15. Effects of Polygoni Multiflori Radix on the Elastase, and Collagenase Activities and the Procollagen Synthesis in Hs68 Human Fibroblasts The Korea Journal of Herbology · 2014 · 2 citations
    16. Hair Growth Promotion Activity and Its Mechanism of<i>Polygonum multiflorum</i> Evidence-based Complementary and Alternative Medicine · 2015 · 24 citations
    17. Acute Hepatitis Due to Shen-Min Journal of clinical gastroenterology · 2006 · 74 citations
    18. Toxic Hepatitis Induced by Show-Wu-Pian, a Chinese Herbal Preparation Internal Medicine · 2010 · 37 citations
    19. Topically used herbal products for the treatment of hair loss: preclinical and clinical studies Archives of Dermatological Research · 2017 · 25 citations
    20. In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions Journal of Industrial and Engineering Chemistry · 2013 · 25 citations
    21. Exploring the combination and modular characteristics of herbs for alopecia treatment in traditional Chinese medicine: an association rule mining and network analysis study BMC Complementary and Alternative Medicine · 2018 · 23 citations
    22. 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine Journal of acupuncture and meridian studies · 2010 · 19 citations
    23. Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo Archives of Dermatological Research · 2021 · 18 citations
    24. <i>In vivo</i>hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice Pharmaceutical Biology · 2015 · 15 citations
    25. Development Studies of Cuticle Drugs from Natural Resources. I. : Effects of Crude Drug Extracts on Hair Growth in Mice YAKUGAKU ZASSHI · 1988 · 12 citations
    26. Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells International journal of molecular sciences · 2022 · 3 citations
    27. Latín cadurcum 'female genitals' and Hesychian Greek xá8veog `hog': is there any connection between the terms? Maia-rivista Di Letterature Classiche · 2006 · 1 citations
    28. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    29. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    30. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026