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    Did you mean Polycomb Repressive Complex 2?
    Glossary Polycomb Repressive Complex 2

    regulates gene expression by modifying chromatin structure

    Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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    Research 30 of 171

    1. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    2. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    3. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    4. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    5. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    6. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    7. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    8. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    9. PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment EMBO journal · 2016 · 75 citations
    10. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    11. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    12. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    13. 1360 Regulation of bmp signalling in melanogenesis, pigment transfer and melanocyte migration Journal of Investigative Dermatology · 2018
    14. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    15. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    16. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    17. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    18. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    19. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    20. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    21. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    22. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    23. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    24. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    25. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    26. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    27. Wound repair at a glance Journal of Cell Science · 2009 · 733 citations
    28. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    29. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    30. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations