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In this study, Nano-Pulse Stimulation Therapy successfully cleared up to 91% of melanoma tumors in mice with less skin damage compared to cryoablation, which cleared up to 66% of tumors.

This study found that exogenous melatonin enhances the development of secondary hair follicles in Cashmere goats by promoting miRNA-mRNA interactions, specifically via the chi-let-7d-5p/WNT2 axis, which suggests a mechanism for melatonin's effects on hair growth involving microRNA regulation.

This paper reports two cases of finasteride-induced melasma, expanding the limited literature on this side effect, and underscores the importance of considering 5-ARI exposure in patients with new or persistent hyperpigmentation, especially among those with darker skin.

This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.

This study optimized a screening assay to identify molecules that inhibit or enhance TRPM5 ion channel activity, which may have implications for treating dysfunctions linked to cardiac arrhythmias and diabetes.

This study found that DNA hypermethylation was present in melasma lesions, and treatments with sunscreen, niacinamide, and retinoic acid were associated with decreased methylation and clinical improvement.

This study found that applying a low intensive pulse magnetic field significantly accelerated wound healing in rats by promoting the proliferation and differentiation of skin epidermal stem cells.

This review examined clinical studies on topical melatonin for skin protection and found strong evidence that it effectively prevents skin damage from radiation, but noted limited clear evidence for its anti-aging and hair growth benefits due to study design limitations and combined treatments.

This study found that mouse embryoid bodies adhered quickly and differentiated efficiently into cardiomyocytes on negatively charged poly(sodium p-styrene sulfonate) hydrogels, similar to their behavior on gelatin-coated polystyrene.

In this animal study, a topical gel containing ethyl-methyl-hydroxypyridine succinate showed potential in accelerating hair regrowth and improving skin biochemical parameters in rats with chemically induced alopecia, suggesting its possible benefit for alopecia related to oxidative stress.

At a workshop highlighted during the 2025 ESPCR meeting, researchers discussed the challenges and variability in culturing skin-related cells, identifying key factors such as media composition and species differences that affect experimental reproducibility, and emphasized the importance of transparent practices to advance pigment cell research.

This study identified ALDH1A1 as a regulator of melanogenesis and suggests its inhibition, through agents like cyanamide, may be a promising therapeutic approach for treating hyperpigmentation disorders such as melasma.

This review suggests that melasma may be a photoaging skin disorder affecting genetically predisposed individuals, which could significantly influence its treatment and prevention strategies.

In this study, topical extracts of Mylabris phalerata Pall. were observed to promote hair growth in mice, potentially indicating its benefit for hair growth activity at low doses.

This study reports that melatonin influenced HaCaT cell proliferation, with high concentrations reducing DNA synthesis and low concentrations enhancing it after 24 hours.

This study found that prevelex coatings on microwell array devices enhanced the formation of uniform cell spheroids and enabled the development of hair follicles in tissue engineering applications.

This source explores melatonin's roles beyond circadian rhythm regulation, reporting its benefits in skin conditions like dermatitis, melasma, alopecia, psoriasis, and skin aging due to its antioxidant, anti-inflammatory, and immunomodulatory properties, while highlighting the need for more trials on optimal dosing and long-term safety.

This study found that puerarin, derived from Pueraria thunbergiana, may stimulate melanogenesis and prevent follicular depigmentation in a hair graying mouse model.

This research describes methods to activate melanocyte stem cells during hair follicle regeneration and to isolate melanocytes from neonatal mouse skin, with the aim of studying melanogenesis for potential clinical applications.

This study reports that the side population technique can isolate melanocyte stem cells from human hair follicles, potentially allowing them to be used for skin pigmentation repopulation.

This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.

This study found that PGF2alpha analogues and PGE2 stimulated hair follicle activity in mice, with PGF2alpha analogues also linked to potential side effects like poliosis when used as eye treatments.

This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.

This study explored using 3D models derived from reflectance confocal microscopy to better understand and differentiate melanoma on sun-damaged skin, suggesting enhanced diagnostic possibilities.

This study found that a newly developed peptide, FOL-005, significantly inhibited hair growth and counteracted minoxidil's effects in organ-cultured human male scalp skin and mouse models, without apparent toxicity.

This study observed that the development of the pars intermedia in long-tailed macaques is closely associated with changes in skin pigmentation during pre- and postnatal periods through melanocyte-stimulating hormone and ACTH activity.

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

This study found that finasteride-loaded microemulsions using poloxamer 124 significantly enhanced skin penetration of the drug compared to a standard solution, primarily through targeting hair follicles via the transfollicular pathway, with intercluster, intercellular, and transcellular pathways contributing less.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

In this case study, a 26-year-old female with PLEC mutations and features of muscular dystrophy and myasthenia gravis showed significant improvement in symptoms following steroid treatment.