Melatonin in Dermatology

    September 2025 in “ Indian Dermatology Online Journal ”
    Vineet Relhan, Arunima Ray, Ishan Agrawal, Tarang Goyal
    Studysummary This source explores melatonin's roles beyond circadian rhythm regulation, reporting its benefits in skin conditions like dermatitis, melasma, alopecia, psoriasis, and skin aging due to its antioxidant, anti-inflammatory, and immunomodulatory properties, while highlighting the need for more trials on optimal dosing and long-term safety.
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    Research cited in this study 9

    1. Efficacy and Safety of Topical Rosuvastatin and Melatonin vs. Placebo in Patients with Mild to Moderate Plaque Psoriasis: A Preliminary Randomized Double-Blinded Clinical Trial Skin research and technology · 2024
    2. Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports International Journal of Molecular Sciences · 2023
    3. Melatonin and the Human Hair Follicle Journal of Drugs in Dermatology · 2023
    4. Mechanism of Action and Promising Clinical Application of Melatonin from a Dermatological Perspective Journal of Translational Autoimmunity · 2023
    5. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022
    6. Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea Frontiers in Immunology · 2021
    7. Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions Journal of Investigative Dermatology · 2018
    8. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    9. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004