May 2024 in “Dermatologic surgery” In this study involving 15 women with alopecia, subcutaneous scalp injections of platelet-rich plasma every four weeks for three sessions led to increased hair and hair follicle density at 24 weeks, with common side effects being local swelling and pain.
April 2023 in “The Egyptian Journal of Histology” This study found that platelet-rich plasma improved healing and accelerated scar maturation in rat models of second-degree skin burns, especially noticeable after four weeks of treatment.
70 citations
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June 2017 in “Nature Communications” This study introduced a new technique, 2Phatal, enabling precise apoptotic cell ablation in living animals, revealing unique cell-type differences in apoptosis-related dynamics.
4 citations
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July 2024 in “PubMed” This study found that platelet-rich plasma therapy may improve symptoms and quality of life in adults with moderate to severe atopic dermatitis, although standardized protocols for its preparation need further study.
July 2018 in “International Journal of Research in Medical Sciences” In this study, platelet-rich plasma treatment showed minimal effectiveness for Alopecia Areata but was more effective than no treatment, with a 20% improvement observed compared to 3.3% in the control group.
April 2017 in “Medicina Clínica (english Edition)” This review discusses the diagnosis and management of acquired haemophilia and reports no new findings; the authors highlight the importance of early diagnosis to reduce mortality.
16 citations
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December 2019 in “Journal of Cellular and Molecular Medicine” This study found that sonicated platelet-rich plasma was more effective than calcium chloride-induced platelet-rich plasma in activating hair follicle stem cells and promoting hair follicle regeneration in mice.
1 citations
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July 2023 in “Aesthetic Plastic Surgery” This study discusses the potential psychological impact of platelet-rich plasma treatment for hair loss but reports no standardized protocols or conclusive results, highlighting the need for further analysis.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that psoriasis patients on biologic therapy had significantly lower anti-COVID19 IgG antibody levels after vaccination compared to healthy individuals not on biologic treatment.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.
December 2025 in “Journal of 108 - Clinical Medicine and Phamarcy” This study found differential expression of growth factors and cytokines in umbilical cord blood-derived platelet-rich plasma, with the highest concentrations observed in the B blood type, but also noted weak correlations with ABO blood groups, suggesting other influencing factors.
January 2024 in “Journal of Education, Health and Sport” This review discusses the modern production methods, mechanisms of action, and various uses of platelet-rich plasma in medicine, highlighting promising applications but noting the need for more high-quality research.
205 citations
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April 2013 in “British Journal of Dermatology” In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.
1 citations
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January 2013 in “The Journal of Dermatology” A skin condition called pyodermatitis vegetans was found in a patient with multiple myeloma for the first time.
December 2025 in “Eastern Ukrainian Medical Journal” This study reviews current methods for making and using platelet-rich plasma and fibrin, emphasizing the variability in clinical outcomes due to differences in preparation protocols, and calls for standardized guidelines and large-scale studies for better effectiveness in regenerative medicine.
April 2023 in “Journal of Investigative Dermatology” This study found that ALRN-6924 effectively protected human hair follicles from cyclophosphamide-induced damage in an ex vivo setting, suggesting it may reduce both acute and permanent chemotherapy-induced alopecia.
January 2024 in “International Journal of Trichology” In this laboratory study, researchers found that human platelet-rich plasma (hPRP) significantly improved the proliferation and hair-inductive capacity of human dermal papilla cells (hDPCs) compared to fetal bovine serum, suggesting hPRP as a potential substitute for FBS in expanding hDPCs for clinical hair regeneration therapies.
3 citations
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January 2023 in “PloS one” In this study, hair-follicle-associated pluripotent stem cell implantation improved functional recovery and reduced inflammation in a mouse model of intracerebral hemorrhage.
11 citations
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May 2021 in “Dermatologic clinics” This review discusses platelet-rich plasma and cell-based therapies for hair loss, noting promising results but emphasizing the need for standardization and robust trials to confirm their efficacy.
10 citations
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April 2013 in “Veterinary dermatology” In this study, four dogs with a novel skin disease showed clinical lesions involving verrucous, crusted papules and plaques, and responded variably to immunosuppressive therapy, suggesting an immune-mediated cause.
44 citations
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January 1984 in “Molecular and Cellular Biochemistry” 20 citations
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November 2003 in “American Journal Of Pathology” Fibroblasts from healthy donors can prevent changes seen in recessive epidermolysis bullosa simplex.
2 citations
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May 2022 in “The journal of immunology/The Journal of immunology” In vivo using the C3H mouse model, this study observed that BST2 expression occurs before hair loss in alopecia areata and is followed by an increase in epidermal γδ T cell numbers.
August 2021 in “BMJ Case Reports” This case report details a 27-year-old woman's diagnosis of systemic lupus erythematosus with immune-mediated intravascular haemolysis, which improved with steroid treatment.
November 2023 in “European medical journal. Dermatology” This review found mixed evidence regarding platelet-rich plasma's effectiveness in various medical applications, noting significant limitations like small sample sizes and lack of standardization that necessitate further research.
2 citations
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December 2011 in “[Thesis]. Manchester, UK: The University of Manchester; 2011.” The study suggests that immune privilege collapse in bulge cells and the involvement of pro-inflammatory cytokine interferon-γ contribute to hair follicle stem cell loss in lichen planopilaris.
37 citations
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April 2018 in “Journal of Allergy and Clinical Immunology” This study found that a novel IKZF1 mutation, p.L188V, is linked to juvenile-onset systemic lupus erythematosus and alters B-cell activation by disrupting normal DNA binding.
March 2026 in “Skin Appendage Disorders” This study identified CD28, GZMB, and CD1C as key immune regulators in alopecia areata, highlighting CD28 as a potential therapeutic target with a promising safety profile, using a proteome-anchored multi-omics approach to uncover actionable targets for this autoimmune hair-loss disorder.
May 2026 in “International Journal of Drug Delivery Technology” This study found that high leukocyte platelet-rich plasma was more effective in increasing hair density and patient satisfaction for androgenetic alopecia treatment.
This study identified CD28 as a potential drug target in treating alopecia areata by linking immune signaling pathways to local inflammation, highlighting belatacept as a promising treatment option due to minimal adverse effects and providing insights into autoimmune target discovery.