20 citations
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November 2022 in “Nutrients” This review summarizes existing reports on placenta extract for treating liver injury and discusses its mechanisms but provides no new clinical results.
July 2026 in “Journal of Investigative Dermatology” 1 citations
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January 2016 This review discusses the diverse applications of platelet-rich plasma in tissue repair, aesthetic medicine, and hair restoration, but reports no new clinical results.
This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.
March 2026 in “International Journal of Innovative Technologies in Social Science” This review summarizes current clinical evidence on platelet-rich plasma, highlighting its effectiveness in treating androgenetic alopecia and as an adjunctive therapy for acne scars, while noting challenges in standardizing preparation techniques.
August 2024 in “OBM Transplantation” This article reviews the use of platelet concentrates in regenerative medicine and highlights the need for standardized protocols and more specific clinical studies, without reporting new clinical results.
4 citations
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September 2020 in “PeerJ” This study found that platelet factor 4 in platelet-rich plasma suppresses human hair follicle growth and alters related gene expressions, suggesting potential implications for its use in hair loss treatment.
3 citations
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October 2020 in “Journal of Transfusion Medicine” This review discusses the use and mechanisms of platelet-rich plasma therapy and highlights the need for standardized preparation and application protocols, without reporting new clinical results.
February 2025 in “Clinical Medical Reviews and Reports” In this study, autologous platelet-rich plasma was associated with improved burn wound healing in a 45-year-old male, showing potential as an adjunctive therapy, but broader trials are needed to confirm its effectiveness.
July 2026 in “Current Medical Issues” In this study, using EMLA cream did not adequately control pain during and after scalp PRP injections for androgenetic alopecia, with anxiety and younger age linked to higher pain levels.
10 citations
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November 2023 in “Frontiers in Pharmacology” In this study, researchers developed a self-assembling hydrogel called RADA-PDGF2 and found it to accelerate wound closure in a mouse model due to its pro-proliferative and pro-migratory properties, without causing cytotoxicity or immunogenicity.
December 2019 in “Fayoum University Medical Journal” This study reported that prostaglandin D2 levels were significantly lower in both the serum and tissue of Egyptian patients with alopecia areata compared to healthy controls.
April 2024 in “Cellular signalling” This study on mice found that activating TRPML channels with MLSA1 promoted hair regeneration, accelerated hair cycle transition, and influenced human dermal papilla cells to secrete hair growth promoting factors while reducing hair growth inhibitors and oxidative damage.
37 citations
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January 2011 in “Annals of Dermatology” In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.
17 citations
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August 2024 in “Discover Nano” This review summarizes that polyesters hold promise for vascular tissue engineering due to their mechanical properties and biodegradability, but optimizing their use in repairing damaged blood vessels remains challenging due to the complexity of vascular tissues.
44 citations
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June 2024 in “Regenerative Therapy” This review discusses adverse events potentially linked to platelet-rich plasma therapy, highlighting the need for more high-quality evidence to understand its safety profile and associated risks.
December 1981 in “ビジネスコミュニケ-ション” In this study, TRPV1 signaling was found to play a critical, previously unrecognized role in human sebocyte biology, and targeting this pathway may offer a new approach for managing inflammatory sebaceous gland disorders like acne.
May 2019 in “Clinica chimica acta” This study reported that mice with more diverse gut microbiota showed higher hair levels of certain hormones and 1-AG compared to those with less diverse microbiota, though plasma differences were more complex and varied by stress and sex.
9 citations
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June 2025 in “Journal of Clinical Medicine” The authors concluded that while PRP is a promising and well-tolerated treatment for early to moderate knee osteoarthritis, standardizing preparation protocols, patient selection, and outcome reporting is crucial to enhance comparability and inform clinical practice.
4 citations
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January 2017 in “Biological & pharmaceutical bulletin” This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
2 citations
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January 2023 in “Revista Interfaces Saúde Humanas e Tecnologia” This review discusses platelet-rich plasma's potential for aesthetic procedures like facial rejuvenation and alopecia treatment but reports no new clinical findings; further research is needed.
January 2026 in “JPRAS Open” In this pilot study, PDLLA scalp microinjections showed improvement in physician-rated Global Aesthetic Improvement Scale scores over 12-24 weeks for 90% of patients with non-scarring alopecia, with no serious adverse events reported, although findings remain preliminary due to methodological limitations.
August 2013 in “Annals of Translational Medicine” This review discusses human placental extract's potential for regenerating cartilage and reducing inflammation in osteoarthritis, noting promising in vitro and in vivo results but reports no new clinical outcomes.
4 citations
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February 2024 in “Scientific Reports” This study found that Platelet Rich Plasma is effective as a direct pulp capping agent, comparable to Mineral Trioxide Aggregate, but with potentially better cellular dentinogenic responses and homogenous tissue formation in dogs.
The project developed and tested a method using plasma rich platelets to treat hair loss.
5 citations
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January 2024 in “Fermentation” This study found that fermenting porcine and equine placentas with a specific lactic acid bacterial strain enhanced the moisturizing abilities and cell proliferation properties compared to traditional placental extracts, suggesting their potential for cosmetic applications.
January 2026 in “Frontiers in Cell and Developmental Biology” This review discusses the molecular mechanisms and clinical applications of autologous platelet-derived products for TMJ regeneration, but reports no new clinical results.
August 2016 in “Anaplastology” This study reports that controlled release PRP therapy using dalteparin and protamine micro-particles may be effective for hair growth and skin rejuvenation in women.
April 2020 in “Journal of The American Academy of Dermatology” This letter highlights concerns about transient lymphadenopathy as a potential adverse effect of platelet-rich plasma combined with microneedling for alopecia, emphasizing the need to understand its underlying cause.
5 citations
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July 2023 in “Frontiers in Veterinary Science” This study found that wounds in sheep treated with mesenchymal stem cells and platelet-rich plasma showed improved healing, reduced inflammation and contraction, and better skin structure compared to untreated wounds.