August 1994 in “Molecular Endocrinology” This study found that AtT-20 pituitary cells with higher cAMP-dependent kinase activity had larger calcium currents and significantly increased beta-endorphin release compared to cells with lower kinase activity.
98 citations
,
November 2014 in “PLoS ONE” In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.
70 citations
,
February 2019 in “The journal of immunology/The Journal of immunology” This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.
25 citations
,
January 2010 in “International Journal of Pharmaceutics” This study found that polymeric nanoparticles retained more minoxidil and facilitated superior drug permeation compared to lipid nanoparticles, although premature drug release affected formulation performance.
18 citations
,
November 2007 in “Annals of Surgery” Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.
37 citations
,
March 2018 in “Trends in Plant Science” This review discusses the role of reactive oxygen species in regulating oscillating apoplastic pH gradients and growth in plant root hairs and pollen tubes, reporting no new experimental results.
53 citations
,
January 2009 in “Journal of Investigative Dermatology” In this study, UVB irradiation of organ-cultured human anagen hair follicles in vitro reduced hair elongation and increased cell death, affecting hair growth and regulatory processes.
11 citations
,
July 2021 in “Nanomaterials” This study found that α-13′-carboxychromanol significantly accelerated wound healing and improved tissue quality in a mouse model, especially when delivered with bacterial nanocellulose under diabetic conditions.
8 citations
,
July 2022 in “Frontiers in plant science” This review outlines the current understanding of how pH contributes to root hair development and reports no new experimental findings.
9 citations
,
April 2025 in “International Journal of Nanomedicine” This research highlights a hydrogel system that could significantly improve diabetic wound healing by releasing ibuprofen to both suppress inflammation and promote tissue regeneration, indicating a strong potential for future clinical use.
11 citations
,
July 2021 in “Physiologia Plantarum” In this study, the gene SlPHL1 was identified as a transcription factor in tomatoes that enhances phosphate starvation responses by upregulating specific genes.
355 citations
,
August 2013 in “Acta Biomaterialia” This study found that a nanoparticle-in-nanofiber system significantly accelerated wound healing in rats by promoting angiogenesis and tissue regeneration more effectively than a commercial wound dressing.
46 citations
,
January 2020 in “Theranostics” This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.
46 citations
,
September 2013 in “PLOS ONE” This study identified thyrotropin-releasing hormone (TRH) as a stimulant of wound healing in both frog and human skin models, suggesting it as a potential neuroendocrine wound repair promoter.
34 citations
,
October 2014 in “European journal of pharmaceutics and biopharmaceutics” This study found that adapalene-loaded solid lipid microparticles may enhance targeted drug delivery into sebum due to their similarity to sebum components, although both this formulation and a standard cream showed equivalent follicular penetration.
7 citations
,
September 2024 in “Applied Microbiology and Biotechnology” In this study, researchers observed that Malassezia species show different lipid metabolism and growth patterns depending on pH, with slightly acidic conditions promoting beneficial lipid bio-conversion for skin health, while neutral pH resulted in lower growth and lipid content, potentially negatively impacting the skin.
4 citations
,
January 2013 in “Dissolution Technologies” This study optimized and validated a dissolution test method for immediate-release finasteride capsules, highlighting the need for an official standard due to variability in commercial products.
72 citations
,
January 2003 in “American Journal of Pathology” This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.
248 citations
,
November 2011 in “The EMBO Journal” This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.
22 citations
,
October 2019 in “Cerebral cortex” This study found that testosterone and dihydrotestosterone are crucial for synaptic transmission and spine density in male hippocampal neurons, suggesting sex-specific effects of neurosteroids on brain development.
16 citations
,
September 1964 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that new compounds with anti-androgenic effects were found to counteract testosterone in animals without significant estrogenic activity, indicating potential for managing androgen-related conditions.
7 citations
,
May 2012 in “International Journal of Andrology” This study found that an oral testosterone formulation normalized serum testosterone levels and significantly reduced SHBG in men with experimentally induced hypogonadism after nine days of treatment, suggesting potential efficacy for testosterone deficiency.
11 citations
,
April 2019 in “International Journal of Molecular Sciences” This study found that genetic polymorphisms of OCT1 influence the effectiveness of metformin treatment in improving insulin sensitivity among PCOS patients, suggesting a role for personalized treatment strategies.
7 citations
,
June 2021 in “Cell Proliferation” This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.
January 2025 in “Frontiers in Immunology” This case report details a rare instance of a young male with coexisting autoimmune polyendocrine syndrome type 2 and anti-GAD65 antibody-associated stiff person syndrome, where symptoms improved by adding intravenous immunoglobulin therapy, emphasizing the importance of awareness for early diagnosis and treatment.
19 citations
,
September 2010 in “The American journal of pathology” This study demonstrated that elevated glucocorticoid levels in transgenic mice led to pancreatic exocrine cells transforming into hepatocyte-like cells, resulting in pancreatic dysfunction.
4 citations
,
January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
41 citations
,
December 2019 in “Stem Cell Reviews and Reports” This review discusses the progress in tooth regeneration research and highlights the potential of spatial-temporal release of developmental factors, but it reports no new clinical findings.
125 citations
,
August 2020 in “Frontiers in Immunology” This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.
40 citations
,
November 2021 in “npj Regenerative Medicine” In this study, spiny mice showed superior cardiac recovery after myocardial infarction compared to other mouse strains, with enhanced myocardial preservation and functional stabilization.