The IVIG Treatment Response in Autoimmune Polyendocrine Syndromes Type 2 with Anti-GAD65 Antibody-Associated Stiff Person Syndrome: A Case Report and Literature Review

    January 2025 in “ Frontiers in Immunology ”
    Yulong Yang, Hailin Jiang, Wenming Yang, Han Wang, Meixia Wang, Xiang Li, Peng Huang, Shuzhen Fang, Wenjie Hao, Yue Yang, Furong Zhao, Wei He
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    TLDR IVIG therapy significantly improved symptoms in a patient with APS-2 and SPS.
    This case report and literature review describe a young male with autoimmune polyendocrine syndrome type 2 (APS-2) and anti-GAD65 antibody-associated stiff person syndrome (SPS), initially presenting with hair loss, vitiligo, and eosinophilia. Despite initial treatments, significant symptom improvement, including reduced muscle stiffness and pain, was achieved only after intravenous immunoglobulin (IVIG) therapy. The report highlights eosinophilia as a new clinical phenotype of APS-2 and underscores the complexity of diagnosing and treating APS-2 and SPS, emphasizing the potential effectiveness of IVIG in managing these conditions.
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