The IVIG Treatment Response in Autoimmune Polyendocrine Syndromes Type 2 with Anti-GAD65 Antibody-Associated Stiff Person Syndrome: A Case Report and Literature Review
January 2025
in “
Frontiers in Immunology
”
Studysummary This case report details a rare instance of a young male with coexisting autoimmune polyendocrine syndrome type 2 and anti-GAD65 antibody-associated stiff person syndrome, where symptoms improved by adding intravenous immunoglobulin therapy, emphasizing the importance of awareness for early diagnosis and treatment.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report and literature review describe a young male with autoimmune polyendocrine syndrome type 2 (APS-2) and anti-GAD65 antibody-associated stiff person syndrome (SPS), initially presenting with hair loss, vitiligo, and eosinophilia. Despite initial treatments, significant symptom improvement, including reduced muscle stiffness and pain, was achieved only after intravenous immunoglobulin (IVIG) therapy. The report highlights eosinophilia as a new clinical phenotype of APS-2 and underscores the complexity of diagnosing and treating APS-2 and SPS, emphasizing the potential effectiveness of IVIG in managing these conditions.
