Association Between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome

    April 2019 in “ International Journal of Molecular Sciences ”
    Hui Hua Chang, Yuan-Shuo Hsueh, Yung Wen Cheng, Horng Yih Ou, Meng Hsing Wu
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    TLDR Certain genetic variations in OCT1 may improve insulin sensitivity with metformin in women with PCOS.
    The study, involving 87 women with polycystic ovary syndrome (PCOS) and 113 control women, explored the relationship between polymorphisms in OCT1 and OCT2 and the metabolic response to metformin. It was found that certain single nucleotide polymorphisms (SNPs) in OCT1 (rs683369 and rs628031) were associated with increased insulin sensitivity after six months of metformin treatment in PCOS patients. These findings suggest that OCT1 genetic variations can influence the response to metformin, highlighting the potential for personalized treatment strategies based on individual pharmacogenomic profiles. However, the study also recognized limitations such as a small sample size and the need for further research to confirm these results and develop personalized treatment plans.
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