July 2012 in “Ubaya Repository (University of Surabaya)” This study found that hair growth gel and tonic containing red grape seed extract were physically and chemically unstable under high temperature and humidity conditions over 30 days.
December 2023 in “Sains Malaysiana” In this study, researchers used in silico mutagenesis to identify key calcium-binding sites influencing the stability of Rand protease from Bacillus subtilis, potentially enhancing its application in industries like leather dehairing by improving stability and eliminating the need for additional metal ions during the process.
81 citations
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February 2022 in “Bioactive Materials” This study reported the development of pH-responsive nanoparticles that effectively deliver vancomycin in a controlled manner, demonstrated enhanced antibacterial activity, and showed promise for clinical applications by targeting bacterial infection sites with programmable drug release.
August 2025 in “International Journal of Applied Pharmaceutics” This study developed a stable nanoemulsion-based hair serum containing M. oleifera seed oil, which maintained its physical characteristics and reduced the oil's sticky texture, making it more suitable for hair loss treatment compared to traditional formulations.
April 2025 in “Jurnal Multidisiplin Dehasen (MUDE)” In this study, a hair tonic containing fragrant pandan leaf extract and virgin coconut oil was formulated and evaluated, with most variations demonstrating physical stability except for one formulation, which showed instability in the specific gravity test.
February 2024 in “Trends in Sciences” This study examined the stability of two 5α-reductase inhibitors in Tectona grandis extracts, finding that they are more stable in acidic environments and degrade rapidly under heat and light unless protected, suggesting the need for careful storage when developing anti-hair loss medications.
January 2021 in “Indonesian Journal on Medical Science” This study concluded that a hair tonic combining aloe vera and celery extracts can be formulated, with formula 1 meeting the stability requirements best over a month.
August 2026 in “Pharmacy Reports” This study found that a nanoemulsion hair spray formula with 25% PEG 400 showed promising physicochemical stability, but further research is needed to assess its colloidal stability and efficacy in hair growth.
December 2024 in “Journal of Pharmaceutical Research International” This study found that a topical gel formulation containing Dutasteride-loaded niosomes was stable for 90 days and facilitated improved drug release, suggesting potential for enhanced bioavailability in topical applications.
June 2025 in “Indian Journal of Heterocyclic Chemistry” In this study, researchers developed a precise and rapid method for simultaneously analyzing minoxidil and finasteride in local therapeutic formulations, ensuring that the excipients did not interfere, making it suitable for routine quality control.
December 2023 in “JSFK (Jurnal Sains Farmasi Klinis)/JSFK (Jurnal Sains Farmasi dan Klinis)” This study found that a hair tonic formulated with 0.3% cocoa bean extract demonstrated the best physical stability and effectively promoted hair growth in mice, with results comparable to a positive control when used twice daily for two weeks.
2 citations
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August 2024 in “International Journal of Applied Pharmaceutics” This study found that a hair tonic containing 40% broccoli stalks extract was more effective in promoting hair growth in male white rats compared to lower concentrations, while also maintaining stable physical characteristics and safety during testing.
July 2026 in “Journal of Apitherapy and Nature” This study evaluated a plant-based shampoo formulation's scale-up from laboratory to industrial production, reporting that the product maintained its quality, safety, and stability at each scale while meeting microbiological safety standards.
January 2025 in “Termometer Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran” In this study, researchers tested a tea leaf ethanol extract (Camellia sinensis) hair tonic and found it increased average hair growth compared to positive and negative controls over 28 days, but exhibited some instability and inhomogeneity after accelerated testing.
22 citations
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October 2019 in “International Journal of Nanomedicine” This study suggests that the hydrogel nanoparticle formulation of hair growth-promoting compounds may enhance hair follicle penetration and induce hair growth in tested models, demonstrating its potential as a hair growth treatment.
17 citations
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May 2023 in “Pharmaceutics” This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.
4 citations
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January 2022 in “Current pharmaceutical design” This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.
2 citations
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April 2018 in “Majalah Obat Tradisional” In this study, the FIII micro emulsion formulation of virgin coconut oil and rice bran oil showed the best results for hair growth, increasing rabbit hair length by 1.26 cm in 18 days.
1 citations
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February 2023 in “Applied sciences” This study found that methylcellulose-based hydrogels can effectively deliver growth hormone through the skin, with albumin increasing the hormone's permeation to 93% in simulated in vivo conditions.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the growing popularity and benefits of herbal shampoos, which use plant-based extracts to provide a gentle, effective, and environmentally friendly alternative to conventional chemical shampoos, promoting hair health and eco-sustainability.
October 2024 in “International Journal of Pharma Professional’s Research (IJPPR)” This study developed and characterized Quercetin-loaded nanogels, finding that they showed promising potential for enhanced drug delivery and stability in treating Alopecia, with an optimized batch achieving a drug release of 95.32% over 12 hours.
May 2024 in “Jurnal Penelitian Farmasi dan Herbal” In this experimental study using male rabbits, researchers found that a 7.5% concentration of green tea leaf ethanol extract hair tonic was nearly as effective in promoting hair growth as the positive control, minoxidil, over a 21-day period.
September 2023 in “International Journal of Applied Pharmaceutics” This study found that a topical gel containing Minoxidil and Tofacitinib citrate showed promise for treating alopecia areata, with formulation F5 demonstrating effective drug release and stability in evaluations.
This study reported that the HG3 formulation of a Ketoconazole anti-dandruff gel exhibited superior drug release and antifungal efficacy without causing skin irritation, compared to other formulations tested.
3 citations
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October 2013 This study found that microemulsion and microemulsion-based hydrogels may offer a more effective and sustained topical delivery method for minoxidil compared to conventional solutions for hair loss treatment.
September 2026 in “World Journal of Pharmacy and Pharmaceutical Sciences” In this study, a new hair serum featuring Catharanthus roseus extract was formulated and evaluated, showing a stable and appealing product with potential hair growth-promoting properties, positioning it as a promising herbal alternative to synthetic agents like minoxidil.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights a polyherbal hair formulation that combines various natural ingredients, reporting potential benefits in improving scalp circulation, strengthening hair, and promoting regrowth, which might offer a safer alternative for managing male pattern baldness compared to synthetic drugs.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study formulated and evaluated a herbal anti-dandruff shampoo using natural ingredients, finding that it effectively reduced dandruff, improved scalp and hair health, and presented an economical and safe alternative to synthetic shampoos without significant skin irritation.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study evaluated the development of a herbal anti-dandruff shampoo using natural ingredients like fenugreek, curry leaves, and neem, finding it effective in reducing dandruff and nourishing the scalp without causing irritation, and suggesting it as a safe and economical alternative to synthetic shampoos.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers developed a herbal anti-dandruff shampoo utilizing natural extracts like fenugreek, curry leaves, and neem, finding it safe, effective, and stable for topical use, with the curry leaf variety showing superior cleansing performance.