Somatotropin Penetration Testing From Topical Formulations Applied to the Skin

The document presents a study on the topical application of Somatotropin (STH), a growth hormone, and its potential for systemic distribution. The study used pig skin and a cellulose membrane to trace the permeation of STH from the formulation. The addition of Albumin (ALB) to the hydrogel formulations was found to significantly prolong the permeation process of STH and increase its availability. The most STH permeated from the formulation containing STH in a 1:2 ratio to ALB. The study also found that all tested formulations maintained their initial pH, viscosity, and shear stress values under varying storage conditions, indicating stability. The addition of ALB to the formulations prolonged the permeation process and increased the amount of STH permeated by 14%. The hydrogel formulations were found to be stable, non-irritating, and suitable for application to both hairy and hairless skin.