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LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Sex hormones affect hair growth and loss, and treatments for related hair diseases include various medications, hair transplantation, and light therapy.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Finasteride doesn't affect sleep spindles in men.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Certain medications, especially 5-α reductase inhibitors and neuropsychiatric drugs, are often linked to erectile dysfunction.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Trazodone might help reverse post finasteride syndrome.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.