35 citations,
February 2019 in “Cell Communication and Signaling” BMP6 and Wnt10b control whether hair follicles are resting or growing.
28 citations,
February 2016 in “F1000Research” Understanding glycans and enzymes that alter them is key to controlling hair growth.
20 citations,
September 2021 in “Nature communications” Cat color patterns are determined early in development by gene expression and epidermal changes, with the Dickkopf 4 gene playing a crucial role.
11 citations,
April 2016 in “The American Journal of Dermatopathology” Special and immunohistochemical stains are not routinely needed for diagnosing hair disorders.
72 citations,
April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
66 citations,
March 2019 in “Cellular and Molecular Life Sciences” Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
65 citations,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
51 citations,
January 2003 in “Hormone Research in Paediatrics” Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.
28 citations,
February 2019 in “Genes” Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
4 citations,
January 2019 in “International journal of molecular sciences” Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.
4 citations,
October 2018 in “Cell Stem Cell” Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.
4 citations,
January 2015 in “Hair therapy & transplantation” Hair follicle stem cells could be used to treat the skin condition vitiligo.
July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” The mesenchyme can start hair growth, but the exact signal that causes this is still unknown.
1160 citations,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
759 citations,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
356 citations,
March 2012 in “Trends in Plant Science” Auxin and ethylene hormones both work together and against each other to control plant growth.
277 citations,
July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
211 citations,
October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
165 citations,
June 2007 in “European Journal of Cell Biology” Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
143 citations,
September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
131 citations,
March 2004 in “The American journal of pathology” Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.
121 citations,
May 2009 in “Journal of Ethnopharmacology” Eclipta alba extract may help hair grow similarly to Minoxidil.
111 citations,
January 2007 in “Seminars in cell & developmental biology” Hair, teeth, and mammary glands develop similarly at first but use different genes later.
96 citations,
June 2017 in “Nature Communications” A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.
90 citations,
June 2006 in “The American Journal of Dermatopathology” The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.
86 citations,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
82 citations,
March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
71 citations,
January 2019 in “International journal of biological sciences” Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.
66 citations,
July 2015 in “Journal of Molecular Biology” The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
59 citations,
February 2012 in “Journal of Dermatological Science” Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.