13 citations
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August 2018 in “Clinical Chemistry” This study determined that a total testosterone concentration of ≥5.1 nmol/L identified androgen-producing tumors in women with severe hyperandrogenemia, while a lower threshold of ≥2.2 nmol/L was found for diagnosing pathologic hyperandrogenism in postmenopausal women.
January 2020 in “Medical journal of Dr. D.Y. Patil Vidyapeeth” This study found that polycystic ovarian syndrome (PCOS) is the most common cause of cutaneous manifestations of hyperandrogenism in women of reproductive age, with hirsutism severity correlated to serum testosterone levels.
January 2016 in “Dermatology Review” This review details various skin manifestations linked to different endocrine disorders but does not report any new clinical results.
January 2026 in “Frontiers in Oncology” This case report highlights that in postmenopausal women with severe hyperandrogenism, thorough adrenal and pelvic evaluations, hormonal profiling, and permanent pathology are essential for accurate diagnosis and management of androgen-secreting tumors, such as AGCTs, to prevent misdiagnosis and ensure effective treatment.
5 citations
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April 2013 in “Current Problems in Pediatric and Adolescent Health Care” This review discusses the prevalence and management of polycystic ovary syndrome in women, particularly noting gaps in understanding its presence in adolescents, and reports no new clinical findings.
June 2002 in “Current obstetrics and gynaecology/Current obstetrics & gynaecology” This article discusses various causes and treatment options for hirsutism in women, highlighting the effectiveness of cyproterone acetate and the importance of weight reduction, without presenting new research findings.
January 2021 in “Voprosy ginekologii akušerstva i perinatologii” In this article, the authors detail approaches for diagnosing and managing hyperandrogenism in young women, focusing on conditions like polycystic ovary syndrome and hirsutism, and highlight the importance of differentiating physiological from pathological causes to guide appropriate treatment strategies, often involving combined oral contraceptives.
October 2024 in “Journal of the Endocrine Society” This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
9 citations
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October 2012 in “Frontiers of Hormone Research” This review discusses the causes and treatments of hirsutism, emphasizing identifying potentially life-threatening pathologies, but it reports no new clinical results.
This study found that nisoral treatment in patients with hyperandrogenism was associated with restored menstrual cycles and reduced pathological hair growth, along with decreased testosterone and increased estradiol and progesterone levels.
1 citations
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May 2022 in “Reproductive Endocrinology” This review discusses the complexities of diagnosing and managing hyperandrogenism in women, emphasizing the need for careful evaluation of both clinical signs and biochemical markers without reporting new clinical results.
30 citations
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January 2015 in “BioMed Research International” Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.
October 2025 in “Journal of the Endocrine Society” This case report illustrates a rare instance of mixed germ cell tumor in the pituitary with hyperandrogenism, emphasizing the importance of thorough examination and hormone evaluation in identifying hormonal dysfunctions.
January 2023 in “Open Journal of Endocrine and Metabolic Diseases” This study in Senegal reported that among women with hyperandrogenism, the primary diagnosis was polycystic ovarian syndrome, with symptoms including hirsutism, menstrual disorders, and acne.
November 2022 in “Journal of the Endocrine Society” This case report highlights a rare ovarian steroid cell tumor as the cause of androgen excess in a 36-year-old woman and underscores the importance of thorough preoperative workup to avoid unnecessary surgery.
January 2013 in “Revista Clínica Española” This review discusses female hyperandrogenism, detailing diagnostic criteria and treatment options without reporting new study results; it emphasizes improving health and quality of life for affected women.
November 2020 in “TURKDERM” This study reports that hormonal therapies, particularly combined oral contraceptives, are commonly used and effective in treating acne in women, especially those with hormonal imbalances or specific acne patterns, regardless of their serum androgen levels.
56 citations
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October 2018 in “Journal of The American Academy of Dermatology” This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.
August 2023 in “Revista Contemporânea” This review examines the relationship between fetal metabolic programming and the development of polycystic ovary syndrome, highlighting maternal and environmental factors but reports no new experimental results.
May 2026 in “Актуальні питання педіатрії акушерства та гінекології” In this study of young women with menstrual cycle disorders, researchers found that the type and severity of skin conditions are linked to both androgen levels and local skin receptor expression, suggesting customized treatment strategies could enhance management.
September 2022 in “Curēus” This case report describes a 61-year-old female with hyperandrogenic symptoms, where an ovarian hemangioma with stromal luteinization was identified and surgically removed, resulting in improved symptoms.
April 2020 in “Journal of the Endocrine Society” This case report details a post-menopausal woman with hirsutism and virilization due to rare Leydig cell tumors in both ovaries, underscoring the challenge of detecting such tumors with standard imaging.
April 2020 in “Journal of the Endocrine Society” This case report highlights Leydig cell hyperplasia as a rare cause of increased testosterone and postmenopausal hirsutism, resolved after bilateral salpingo-oophorectomy in a 64-year-old woman.
April 2019 in “Journal of the Endocrine Society” In this case report, a 48-year-old woman's hyperandrogenism, presenting with symptoms like acne and hirsutism, was attributed to a benign Leydig cell tumor, which resolved after surgical removal.
10 citations
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July 2022 in “Journal of the Turkish-German Gynecological Association” In this study, micronutrient intake was associated with androgen levels in women with PCOS, with the association more pronounced in NA PCOS compared to HA PCOS groups.
3 citations
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March 1992 in “Journal of clinical pathology” This review discusses the clinical evaluation and investigation needed for hirsute women, suggesting that most cases require minimal testing unless virilism or severe symptoms are present; no new clinical results are provided.
2 citations
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August 2011 in “Revista Medica De Chile” This case report describes a woman with virilization syndrome who experienced a reduction in androgen levels and reversal of alopecia after removal of a Leydig cell tumor from her ovary.
This report describes a complex case of postmenopausal hyperandrogenism with virilization and concurrent rare ovarian tumors, highlighting the critical role of interdisciplinary collaboration in diagnosing and managing such challenging scenarios.
8 citations
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April 2019 in “Journal of the Endocrine Society” In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.
7 citations
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January 2025 in “Archives of Gynecology and Obstetrics” In this review, the authors aim to improve the differential diagnosis between hyperandrogenic PCOS and NCAH, which could lead to more personalized treatment strategies for patients experiencing hyperandrogenism.