Case Report: Postmenopausal Hyperandrogenism Misled by Adrenal Incidentaloma: A Rare Case of Androgen-Secreting Ovarian Adult Granulosa Cell Tumor and Clinical Implications

    January 2026 in “ Frontiers in Oncology ”
    Conghui Cao, X. Wang
    Studysummary This case report highlights that in postmenopausal women with severe hyperandrogenism, thorough adrenal and pelvic evaluations, hormonal profiling, and permanent pathology are essential for accurate diagnosis and management of androgen-secreting tumors, such as AGCTs, to prevent misdiagnosis and ensure effective treatment.
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    Research cited in this study 7

    1. Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women Clinical Endocrinology · 2025
    2. Approach to Investigation of Hyperandrogenism in a Postmenopausal Woman The Journal of Clinical Endocrinology and Metabolism · 2022
    3. Clinical Case Seminar: Postmenopausal Androgen Excess - Challenges in Diagnostic Work-Up and Management of Ovarian Thecosis Clinical Endocrinology · 2017
    4. Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies European journal of endocrinology · 2017
    5. Management of Endocrine Disease: Hyperandrogenism After Menopause European journal of endocrinology · 2014
    6. How Should Postmenopausal Androgen Excess Be Evaluated? Clinical Endocrinology · 2011
    7. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977