Diagnostic Thresholds for Androgen-Producing Tumors or Pathologic Hyperandrogenism in Women Using Total Testosterone Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry

    August 2018 in “ Clinical Chemistry ”
    Anu Sharma, Ekta Kapoor, Ravinder Singh … Dana Erickson
    Studysummary This study determined that a total testosterone concentration of ≥5.1 nmol/L identified androgen-producing tumors in women with severe hyperandrogenemia, while a lower threshold of ≥2.2 nmol/L was found for diagnosing pathologic hyperandrogenism in postmenopausal women.
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    Research cited in this study 11

    1. Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies European journal of endocrinology · 2017
    2. Of PCOS Symptoms, Hirsutism Has the Most Significant Impact on the Quality of Life of Iranian Women PLOS ONE · 2015
    3. Cardiovascular Risk Factors and Events in Women with Androgen Excess Journal of Endocrinological Investigation · 2014
    4. Management of Endocrine Disease: Hyperandrogenism After Menopause European journal of endocrinology · 2014
    5. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    6. The Investigation and Management of Severe Hyperandrogenism Pre- and Postmenopause: Non-Tumor Disease Is Strongly Associated with Metabolic Syndrome and Typically Responds to Insulin-Sensitization with Metformin Gynecological Endocrinology · 2008
    7. Androgen Excess in Women: Experience with Over 1000 Consecutive Patients The Journal of Clinical Endocrinology and Metabolism · 2004
    8. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    9. Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study The Journal of Clinical Endocrinology and Metabolism · 1998
    10. Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study The Journal of Clinical Endocrinology and Metabolism · 1998
    11. A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia Clinical Endocrinology · 1994

    Related research 2

    1. Prevalence of Functional Disorders of Androgen Excess in Unselected Premenopausal Women: A Study in Blood Donors Human Reproduction · 2012
    2. Hyperandrogenism in Women: Polycystic Ovary Syndrome Hanyang Medical Reviews · 2012