Advanced Hyperandrogenism in a Postmenopausal Woman: Case Report

August 2011 in “ Revista Medica De Chile ”

Patricio Andrés Salman M, Mauricio Cuello F, Marianne Kolbach, Roger Gejman, Eugenio Arteaga U

hyperandrogenism Leydig cell tumor testosterone androgenic alopecia clitoromegaly hirsutism bilateral oophorectomy ovarian tumors high testosterone hair loss ovary removal

TLDR A postmenopausal woman's high testosterone levels and symptoms improved after removing a tumor from her ovary.

In 2011, a 76-year-old postmenopausal woman was diagnosed with advanced hyperandrogenism caused by a Leydig cell tumor in her ovary. She had high testosterone levels of 711 ng/dl and symptoms such as androgenic alopecia, clitoromegaly, and hirsutism. Imaging showed enlarged ovaries and a cyst. After a bilateral oophorectomy, which confirmed the tumor's presence, her androgen levels decreased, and her alopecia significantly improved. This case underscores the need to consider ovarian tumors in postmenopausal women with hyperandrogenism, as oophorectomy can be an effective treatment.

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research Plasma C19 Steroid Sulfate Levels and Indices of Androgen Bioavailability in Female Pattern Androgenic Alopecia

32 citations, January 1990 in “Clinical Endocrinology”

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.