8 citations
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January 2024 in “Current Research in Food Science” This study found that using composite alginate hydrogels containing Aloe vera, CMC, and tragacanth can improve the encapsulation efficiency and protect pumpkin seed protein hydrolysates from degradation during simulated gastrointestinal digestion, potentially increasing their applicability as functional food components.
January 2025 in “Nanotechnology Reviews” This study reported a green synthesis method for copper oxide nanoparticles using pumpkin seed extract, achieving significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects against certain cancer cell lines, indicating potential biomedical applications for these eco-friendly nanomaterials.
In this study, roasting fluted pumpkin seeds decreased moisture, crude protein, oxalate, and other anti-nutrients while increasing ash, crude fiber, carbohydrates, and certain minerals after 60 minutes, potentially enhancing their nutritional value.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This preliminary study of Alopecia Areata identified limited expression of certain metabolic transporters and enzymes in hair follicle immune cells, providing early insight into their unique energy needs.
67 citations
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February 2015 in “Life Sciences” This review discusses phytotherapy options for managing benign prostatic hyperplasia, noting some herbal agents show promise in trials for mild-moderate symptoms but more evidence is needed for others.
54 citations
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May 2017 in “Biomedicine & Pharmacotherapy” This review discusses the nutrient profile and potential health benefits of pumpkin and watermelon seeds, concluding they are underutilized and could be developed into various nutraceuticals.
54 citations
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September 2002 in “Annals of Pharmacotherapy” This review discusses various herbal therapies, such as Serenoa repens and Pygeum africanum, for treating benign prostatic hyperplasia, noting their potential but highlighting unresolved questions about their efficacy and safety.
40 citations
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August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
26 citations
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April 2019 in “Journal of Cosmetic Dermatology” This review discusses the potential of herbal treatments like Saw palmetto, Green tea, and Rosemary as alternatives to conventional drugs for androgenetic alopecia, noting that these herbs may inhibit the 5-alpha-reductase enzyme and reduce hair loss with fewer side effects.
14 citations
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October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
11 citations
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November 2022 in “JAMA dermatology” This review suggests that certain nutritional supplements may have a potential role in improving hair loss, though evidence quality varies, and such treatments should be discussed collaboratively between physicians and patients.
10 citations
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June 2019 in “International Journal of Cosmetic Science” This review discusses the potential benefits of phytochemicals for hair care and emphasizes the need for more robust preclinical and clinical studies, without reporting new clinical results.
6 citations
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April 2025 in “Frontiers in Sustainable Food Systems” This review highlights the potential of valorizing vegetable waste by extracting valuable biomolecules for use in food, nutraceuticals, and energy, noting that while promising methods exist, several niche areas lack sufficient research on a global scale.
4 citations
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October 2025 in “Molecules” This study concluded that extracts from fermented pumpkin peel and pulp, processed with Lactobacillus strains and kombucha, may serve as multifunctional cosmetic ingredients, offering antioxidant protection, anti-aging, and skin regeneration benefits by demonstrating cytoprotective effects and reducing inflammatory cytokines in cell assays.
3 citations
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February 2024 in “International Journal of Pharmaceutical Sciences Review and Research” This study suggests that a herbal oil formulation combining various plant and oil ingredients may effectively promote healthy hair growth and address concerns like baldness, dryness, and dandruff, supported by favorable evaluations of its physical and chemical properties.
3 citations
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August 2020 in “PubMed” This review discusses the absence of clinical trials on natural ingredients for managing Central Centrifugal Cicatricial Alopecia and highlights a need for more research.
2 citations
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January 2022 in “Dermatologic Therapy” Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.
1 citations
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August 2025 in “Seeds” This review examines the potential of Cucurbitaceae seeds, such as those from watermelon, melon, and pumpkin, as sustainable and innovative ingredients in cosmetics, highlighting their rich bioactive composition and benefits for skin and hair, despite challenges like environmental instability and low permeability.
1 citations
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June 2014 in “Vìsnik farmacìï” This study developed an emulsion formulation with optimal properties for androgenetic alopecia treatment using saw palmetto and Japanese Sophora extracts, evaluated for stability and release of active ingredients.
July 2026 in “Journal of the American Academy of Dermatology” Rosemary oil may be a promising and affordable treatment for hair loss.
This study reviews the use of natural products, like herbal extracts and essential oils, in treating male pattern baldness, noting their potential benefits compared to conventional therapies that may carry side effects or ethical concerns.
This study found that nanostructured lipid carriers enabled effective follicular delivery and accumulation of anti-hair loss drugs like dutasteride in mice, suggesting potential for reduced dosage frequency.
March 2026 in “Journal of the American Academy of Dermatology” This clinical review evaluates current evidence on various adjunctive therapies for androgenetic alopecia, highlighting modest benefits for some interventions but emphasizing significant gaps and the need for rigorous, high-quality research to guide effective management strategies.
January 2026 in “Frontiers in Nutrition” This study found that various dietary supplements positively impacted hair density and were well-tolerated among patients with androgenetic alopecia, suggesting they may be useful adjuncts or alternatives to standard treatments.
December 2025 in “International Journal of Advanced Research” This study found that evidence for the efficacy of herbal and traditional treatments for alopecia is varied, with some key positive findings, such as the effectiveness of rosemary oil and pumpkin seed oil in increasing hair count.
December 2025 in “Brazilian Journal of Hair Health” This review highlights that natural DHT blockers like saw palmetto and pumpkin seed oil show promise in managing androgenetic alopecia, though clinical data varies, and further research is needed to confirm their efficacy and safety in comparison to conventional pharmaceuticals.
August 2025 in “Dermatological Reviews” This review reports that stem cell-based therapies, natural oils, and low-level laser therapy may offer promising and safe alternative treatments for alopecia, although further standardized trials are needed for confirmation.
This manuscript reviews the multifaceted causes of female hair loss, including hormonal imbalances and nutrient deficiencies, and suggests that non-pharmaceutical options like saw palmetto and curcumin show promise in enhancing hair density, though further studies are needed to confirm their effectiveness and safety.
May 2025 in “ID on line REVISTA DE PSICOLOGIA” This study evaluated the effects of pumpkin seed oil and rosemary essential oil combined with electrotherapy on androgenetic alopecia in stressed young women, finding no statistically significant differences between treatment groups and suggesting further research is needed to assess the oils' efficacy.
This study concluded that phytotherapy offers a potentially effective and safer alternative to conventional treatments for androgenetic alopecia by reducing hair loss progression without the usual adverse effects.