Synthesis of Cu4O3 Nanoparticles Using Pumpkin Seed Extract: Optimization, Antimicrobial, and Cytotoxicity Studies

    January 2025 in “ Nanotechnology Reviews ”
    Azhar U. Khan, Azmat Ali Khan, Nazia Malik, Jun Her, Mona Gupta, Subhranshu Panda, Khalid Imtiyaz, M. Moshahid A. Rizvi, Mohammed Mushtaque, Sudhakar Bansod, Masita Mohammad, Min Kim, Kyungsoo Pyo, Mahboob Alam
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    Studysummary This study reported a green synthesis method for copper oxide nanoparticles using pumpkin seed extract, achieving significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects against certain cancer cell lines, indicating potential biomedical applications for these eco-friendly nanomaterials.
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    This study explores a green synthesis method for copper oxide (Cu4O3) nanoparticles using pumpkin seed extract, which acts as both a reducing and stabilizing agent. The nanoparticles, sized between 8.92 and 55.84 nm, were characterized by various techniques and showed a maximum yield of 89.87% under optimized conditions. They exhibited significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects on lung and colon cancer cell lines. Computational studies revealed a moderate HOMO–LUMO energy gap, suggesting potential interactions with biological systems. These results highlight the potential biomedical applications of these eco-friendly nanoparticles.
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