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Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Glioblastoma cells can make androgens, which might help the tumor grow.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Certain drugs that block specific enzymes can help treat prostate diseases.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Low androgen levels can still cause female pattern hair loss.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

More research is needed to understand how testosterone is maintained in adult males.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Polycystic Ovary Syndrome (PCOS) is a hormonal disorder in women that can cause infertility and other health issues, and it may be improved by treatments that increase insulin sensitivity.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

The document concludes that various drugs can manage symptoms and metabolic issues in women with PCOS.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

New information suggests that metformin might help more women with PCOS and infertility, not just those with glucose issues.