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Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Certain drugs that block specific enzymes can help treat prostate diseases.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Glioblastoma cells can make androgens, which might help the tumor grow.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Low androgen levels can still cause female pattern hair loss.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.