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This case report emphasizes the importance of early diagnosis of Swyer Syndrome in adolescents with slow pubertal progression and primary amenorrhea due to the high risk of germ cell cancers.

This study found that administering dutasteride did not change spermatogenesis or oxidative stress levels in rat testes, though further research is needed to confirm these findings.

This study reported that ketoconazole may effectively normalize menstruation and reduce testosterone and hair growth in women with ovarian hyperandrogenism, though its safety needs further evaluation.

This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.

Alopecia areata's causes are unclear, treatments exist but relapses are common.

This study found that GTx-024 and Danazol had similar effects to dihydrotestosterone on uterine tissue in mice, while GTx-007 showed minimal impact on the parameters tested.

Ovarian hyperthecosis caused high testosterone and virilization symptoms in a 60-year-old woman, which improved after surgery.

This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.

A new compound was made that might help treat diseases related to male hormones.

This study found that topical γ‐Oryzanol significantly stimulated sebaceous gland cell activity and sebum production in rats.

This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

In this case report, the authors describe the diagnosis and management of a rare case of hyperandrogenism in a postmenopausal woman, attributed to coexisting ovarian Leydig cell and Brenner tumors, with improvement in symptoms following bilateral salpingo-oophorectomy.

In this study, researchers developed and tested a novel peptide, AMHR2BP, which mimics the function of Anti-Müllerian hormone to protect ovarian follicles in mice, showing promise for preserving ovarian health during chemotherapy without causing toxicity.

In this study, researchers characterized the clinical features of ophiasis, an uncommon type of alopecia areata, and proposed a new subtype classification that may help predict treatment response and guide management, noting that ophiasis generally has a chronic and refractory nature.

This study found that among women with polycystic ovary syndrome, higher levels of the hormones estrone and free testosterone were associated with an increased cardiometabolic risk, especially in those who were overweight or obese.

This study developed a new crystallization method using solid solution formation to purify finasteride by effectively removing contamination with dihydrofinasteride.

In this case study, a 14-year-old boy with treatment-resistant diffuse alopecia areata achieved complete hair regrowth following three monthly sessions of microneedling combined with injections of triamcinolone, dutasteride, and synthetic exosomes, suggesting that exosome-based therapy could be a promising alternative for managing refractory autoimmune alopecia.

This paper summarizes proceedings from a PCOS Special Interest Group, reporting recent advances in the understanding of PCOS follicular abnormalities, associated cardiovascular risks, and dermatological issues, but does not present new clinical findings.

This study found that trilostane treatment led to complete hair regrowth in three Alaskan malamutes with ACTH-stimulated elevated 17-hydroxyprogesterone levels within 6 months without any recognized adverse effects.

This study found that neurosteroid withdrawal significantly increased hippocampal GABA-A receptor α4 subunit expression in female mice, confirming an association between neurosteroid withdrawal and altered receptor expression.

This study suggests that stress may worsen Tourette syndrome symptoms in mice by increasing allopregnanolone synthesis, with findings supporting finasteride as a potential treatment to manage symptom fluctuations.

This review discusses the similarities in clinical, endocrine, and ultrasonographic features between PCOS and other disorders with excessive androgen secretion, emphasizing the importance of accurate diagnosis but reports no new clinical results.

This study found that several synthesized compounds were potent inhibitors of human steroid 5alpha-reductase type 2 and reduced prostate weights in treated rats, with compound 15 showing promise for potency in humans.

In this study, male-derived brain tissue exhibited higher cell death following ischemia compared to female-derived tissue, and certain steroid hormones showed different neuroprotective effects depending on the sex of the tissue.

In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.

This study found that in animal models of Tourette syndrome, stress-induced tic-like behaviors and sensorimotor gating deficits were reduced by finasteride, suggesting a role for neurosteroids like allopregnanolone.

This study found that human skin with hair follicles and sebaceous glands absorbed significantly more steroids than scar skin without these appendages, indicating their role in steroid penetration.

In this case study, a 68-year-old woman with hyperandrogenism and presumed ovarian origin responded well to GnRH agonist therapy, normalizing testosterone levels and stabilizing blood pressure, suggesting its effectiveness as a non-surgical treatment option.