Effect of Neurosteroid Withdrawal on Hippocampal GABA-A Receptor Alpha4-Subunit Expression in Female Mice

March 2008 in “ The FASEB Journal ”

Zheng Yc, Doodipala Samba Reddy

neurosteroid progesterone progesterone receptor PRKO mouse model finasteride allopregnanolone GABA‐A receptor α4 subunit hippocampus Propecia

TLDR Neurosteroid withdrawal increases α4 subunit expression in the hippocampus, which may relate to catamenial epilepsy in women.

The study investigated the effects of neurosteroid withdrawal on hippocampal GABA-A receptor α4-subunit expression in female mice. Researchers found that withdrawal from allopregnanolone, a neurosteroid derived from progesterone, led to a significant increase in α4 subunit expression in the hippocampus of wild-type mice. This finding was relevant to understanding catamenial epilepsy in women, as it suggested that changes in neurosteroid levels could influence seizure susceptibility. The study utilized a PRKO mouse model and involved treating female mice with progesterone for 7 days, followed by finasteride co-administration, to assess changes in α4 subunit mRNA levels using TaqMan real-time RT-PCR. The results confirmed that neurosteroid withdrawal was linked to synaptic plasticity alterations in the hippocampus.

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