SUN-106 Nonsurgical Management of Hyperandrogenism in a Postmenopausal Woman

    October 2025 in “ Journal of the Endocrine Society ”
    Ellil Krishnaraju, Farah Meah
    TLDR Goserelin injections can effectively manage hyperandrogenism symptoms in postmenopausal women who can't have surgery.
    A 68-year-old postmenopausal woman with hyperandrogenism, presenting with increased facial hair and a deeper voice, was treated nonsurgically due to her poor surgical candidacy. Despite elevated testosterone levels and stable adrenal imaging, she was managed with Goserelin injections, which normalized her testosterone levels and improved symptoms. The case suggests that while bilateral oophorectomy is the definitive diagnostic and treatment approach for ovarian androgen secretion, GnRH agonists like Goserelin can effectively control symptoms and hormone levels in patients who cannot undergo surgery. The exact source of androgen excess, whether ovarian or adrenal, remains undetermined.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 8 results

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 2 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  6 upvotes 2 years ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  38 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Spironolactine Update: 2 months (34, Female)

      in Female  20 upvotes 8 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

    Similar Research

    5 / 1000+ results