Impact of Dutasteride on Spermatogenesis and Oxidative Stress in Rats

April 2020 in “ Archivos españoles de urología ”

Abdullah Gül, Murat Gül, Şule Yurdagül Özsoy, Tülin Saraç, Duygu Sultan Çelik, Atilla Semerciöz, Ege Can Şerefoğlu

dutasteride DHT LH testosterone FSH ROS Avodart dihydrotestosterone luteinizing hormone follicle-stimulating hormone reactive oxygen species

TLDR Dutasteride does not seem to change rat spermatogenesis or oxidative stress.

In a study conducted on 18 male Sprague-Dawley rats, the impact of dutasteride on spermatogenesis and oxidative status was investigated. The rats were divided into two groups: control (n=8) and dutasteride (n=10). The results showed that DHT (7.35 ± 0.35 vs. 10.54 ± 0.95, p<0.001) and LH levels (0.32 ± 0.009 vs. 0.43 ± 0.01, <0.001) were significantly lower in the treatment group compared to the controls, while testosterone levels were higher in the dutasteride group (3.41 ± 1.12 vs.1.52 ± 0.34, p<0.001). However, the Johnsen score, serum FSH levels, and serum and tissue ROS levels were similar between the two groups. The study concluded that the administration of dutasteride does not appear to modify spermatogenesis and oxidative burden in rats, but further investigations are required to confirm these findings.

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