Clinical Characteristics, Subtype Classification, and Prognostic Factors of Ophiasis: A Retrospective Study of 150 Patients with Therapeutic Implications

    February 2026 in “ Journal of the American Academy of Dermatology ”
    Fanshu Li, Wenhan Zhang, Chen Wang … Cheng Zhou
    Studysummary In this study, researchers characterized the clinical features of ophiasis, an uncommon type of alopecia areata, and proposed a new subtype classification that may help predict treatment response and guide management, noting that ophiasis generally has a chronic and refractory nature.
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    Research cited in this study 9

    1. Alopecia Areata Nature Reviews Disease Primers · 2025
    2. Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective, Multivariate Analysis of 70 Cases from a Single Center The Journal of Dermatology · 2025
    3. Predictors And Management Of Inadequate Response To JAK Inhibitors In Alopecia Areata American Journal of Clinical Dermatology · 2024
    4. Coexistent Frontal Fibrosing Alopecia with Ophiasis Pattern Alopecia Areata in a Young Female: A Case Report and Review of the Literature Clinical Case Reports · 2024
    5. Refractory Alopecia Areata With Single Hairs Imitating Frontal Fibrosing Alopecia: A Prospective Observational Study International Journal of Dermatology · 2023
    6. Lichen Planopilaris and Frontal Fibrosing Alopecia: Review and Update of Diagnostic and Therapeutic Features Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2022
    7. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    8. Diffuse Variants of Scalp Lichen Planopilaris: Clinical, Trichoscopic, and Histopathologic Features of 40 Patients Journal of the American Academy of Dermatology · 2019
    9. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014