Treatment of Alopecia Areata in Pre-Adolescent Children with Oral Tofacitinib: A Retrospective Study

    October 2020 in “ Pediatric Dermatology ”
    Rebekka Jerjen, Nekma Meah, Lara Trindade de Carvalho, Dmitri Wall, Samantha Eisman, Rodney Sinclair
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    TLDR Oral tofacitinib may effectively treat hair loss in children with alopecia areata.
    In a retrospective study at Sinclair Dermatology in Melbourne, Australia, 14 pre-adolescent children aged 7 to 11 with alopecia areata were treated with oral tofacitinib. After an average of 9 months, 9 patients showed clinically significant improvement in their Severity of Alopecia Tool (SALT) scores, with 3 achieving complete remission and 7 showing over 50% improvement. The median SALT score improvement was 67.7%. While the results suggest that tofacitinib could be an effective treatment for AA in pre-adolescents, the study's limitations, such as its small sample size, retrospective nature, lack of a control group, potential referral bias, and the concomitant use of other medications like oral minoxidil, indicate that further research is necessary to confirm these findings.
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      community 22F. Should I even bother getting a biopsy? Is there any point?

       7 upvotes 8 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.
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      community What else is good. Besides the big 3.

      in Chat  34 upvotes 3 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 6 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

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