Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective, Multivariate Analysis of 70 Cases from a Single Center

    January 2025 in “ The Journal of Dermatology
    Moyuka Wada‐Irimada, Takehiro Takahashi, Mana Sekine, Toshiki Okazaki, Takuya Takahashi, Tomoko Chiba, Emi Yamazaki, Kosuke Shido, Toshiya Takahashi, Masato Mizuashi, Yoshihide Asano
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    TLDR Certain patient traits can predict better hair regrowth with baricitinib in severe alopecia areata.
    This study analyzed 70 severe alopecia areata (AA) patients treated with baricitinib at Tohoku University Hospital to identify predictors of treatment response. After 9 months, 41% of patients achieved a SALT score of ≤20, indicating significant hair regrowth. Multivariate analysis revealed that shorter disease duration (≤4 years), history of intravenous methylprednisolone pulse (IVMP) therapy, a SALT score of ≤95 at treatment initiation, and female sex were independent predictors of positive outcomes. Additionally, the type of AA significantly affected responses, with ophiasis alopecia showing the poorest improvement. These findings suggest that specific patient characteristics can predict the efficacy of baricitinib in treating severe AA.
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