Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective, Multivariate Analysis of 70 Cases from a Single Center

    January 2025 in “ The Journal of Dermatology
    Moyuka Wada‐Irimada, Takehiro Takahashi, Mana Sekine, Toshiki Okazaki, Takuya Takahashi, Tomoko Chiba, Emi Yamazaki, Kosuke Shido, Toshiya Takahashi, Masato Mizuashi, Yoshihide Asano
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    TLDR Certain patient traits can predict better hair regrowth with baricitinib in severe alopecia areata.
    This study investigated predictive factors for the efficacy of baricitinib in treating severe alopecia areata (AA) by analyzing 70 patients over 9 months. The primary outcome was achieving a Severity of Alopecia Tool (SALT) score of ≤20. Results showed that 41% of patients reached this score. Key predictors for positive treatment outcomes included a shorter disease duration (≤4 years), a history of intravenous methylprednisolone pulse (IVMP) therapy, a SALT score of ≤95 at the start of treatment, and being female. The type of AA also influenced responses, with ophiasis alopecia (OA) showing the poorest improvement. These findings highlight the importance of considering individual patient characteristics when predicting responses to baricitinib in AA treatment.
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