Effectiveness and Safety of Baricitinib in Patients With Moderate-to-Severe Refractory Alopecia Areata in Real World: An Open-Label, Single-Center Study

    December 2023 in “ Journal of Cosmetic Dermatology ”
    Lingbo Bi, Chaofan Wang, Yimei Du, Tong Su, Zhao Min, Xuewen Lin, Weifei Fan, Weiyuan Sun
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    TLDR Baricitinib effectively and safely improves hair growth in patients with severe alopecia areata.
    The study involved 32 patients with moderate to severe alopecia areata (AA) who were unresponsive to traditional treatments. These patients were treated with baricitinib, a JAK inhibitor, for 24 weeks. The results showed a significant decrease in the Severity of Alopecia Tool (SALT) score from baseline at week 12 and 24, indicating improved hair growth. By the end of the study, 68.75% of patients reported over 80% hair covering of the scalp. Side effects were mild and included transient platelet elevation, elevated transaminase, dizziness, tonsillitis, and acne. The study concluded that baricitinib is effective and safe for treating patients with refractory AA at moderate to severe levels.
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