Late-Onset Alopecia Areata: A Retrospective Cohort Study

    January 2017 in “ Dermatology
    Anna Lyakhovitsky, Shlomo Gilboa, Aliza Eshkol, Aviv Barzilai, Sharon Baum
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    TLDR People who get alopecia areata after age 50 usually have mild symptoms, high chances of hair regrowth, and often have other health conditions.
    The retrospective cohort study from 2009 to 2015 included 29 patients with late-onset alopecia areata (AA), defined as onset at age 50 or above, out of 288 patients with AA. The study found a significant female predominance (86.2%), with a female-to-male ratio of 6.2:1. A family history of AA was present in 17.2% of participants, thyroid disease in 31%, and atopic background in 6.9%. Stressful events were reported by 58.6% of participants. The disease was generally mild and patchy, with 82.8% of participants experiencing complete hair regrowth and 37.9% experiencing relapse. The study concluded that late-onset AA is characterized by less extensive disease, high remission rates, and frequent relapses, with 79.3% of participants having at least one co-existing systemic disease and 10.3% reporting a malignancy. Treatments were mainly topical, and initial hair regrowth was typically seen within 3 months. The study's limitations include its retrospective design, small sample size, and limited follow-up, highlighting the need for further research.
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