September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that while niche architecture optimizes organ efficiency during hair follicle growth, it is not essential for the function of stem cell-derived tissues.
12 citations
,
January 1999 in “Journal of Animal Science” This study observed that combined treatment with thyroxine and hydrocortisone increased lipid accretion and fat cell development in hypophysectomized fetal pigs, suggesting a key role of these hormones in fetal adipogenesis.
3 citations
,
January 2024 in “Frontiers in Endocrinology” This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.
February 2017 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Hair cortisol measurement is a promising, non-invasive tool for monitoring cortisol exposure over time.
6 citations
,
May 2021 in “Stem Cell Reviews and Reports” This study identified and characterized progenitor cells from equine feet that may play a role in the pathogenesis and recovery of laminitis, suggesting potential therapeutic targets for treatment.
296 citations
,
October 2018 in “General and Comparative Endocrinology” This review discusses the use of hair cortisol concentration as a marker for chronic stress and long-term cortisol secretion in animals, highlighting its benefits and the need for standardized sampling protocols.
3 citations
,
July 2019 in “Fibers And Polymers/Fibers and polymers” 71 citations
,
January 2012 in “PloS one” This study observed that after hair cell loss in the mouse cochlea, supporting cells were replaced by migrating non-specialised cells, with genetic background affecting the rate of tissue re-organization.
56 citations
,
January 1970 in “Cell and Tissue Research” August 2024 in “Clinical Case Reports” This case study reports on a rare benign skin tumor known as Pilomatricoma in the lower left orbital region of a 32-year-old male, highlighting its characteristic histopathological features and emphasizing the importance of surgical excision for successful treatment and minimal recurrence risk.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.
11 citations
,
June 2010 in “Medical Molecular Morphology” 7 citations
,
January 2017 in “Stem Cells International” This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.
479 citations
,
January 2005 in “BioEssays” This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.
19 citations
,
May 2008 in “Applied spectroscopy” This study found that human hair cuticle and cortex have different protein structures, with beta-sheet and disorder configurations in the cuticle and alpha-helical structures in the cortex.
19 citations
,
September 2007 in “The Journal of Steroid Biochemistry and Molecular Biology” Glucocorticoid receptors help regulate genes important for skin health and hair growth.
26 citations
,
March 2009 in “Dermato-endocrinology” This review discusses the evaluation, clinical presentation, and cutaneous manifestations of congenital adrenal hyperplasia, focusing on differential diagnosis challenges with polycystic ovary syndrome, and reports no new clinical findings.
September 2016 in “Journal of dermatological science” The researchers reported that the OVOL1-OVOL2 axis may play a role in hair follicle differentiation and tumorigenesis, and OVOL1 and OVOL2 are potential diagnostic markers for pilomatricoma and pilomatrix carcinoma.
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.
30 citations
,
January 2001 in “Journal of the American Veterinary Medical Association” This study found that adrenal sex hormone levels were elevated in neutered dogs with hypercortisolemia, except for testosterone, highlighting the importance of ruling out hypercortisolemia when diagnosing adrenal hyperplasia syndrome.
149 citations
,
July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
27 citations
,
May 2011 in “Current Opinion in Ophthalmology” This study reports that a new transplantation technique using tissue-engineered stem cells successfully reconstructed corneal epithelium in an animal model of severe ocular surface disease.
61 citations
,
August 1993 in “PubMed” This study found that solid basal cell epitheliomas and the outer root sheath of human hair follicles display nearly identical cytokeratin profiles, suggesting a potential origin connection.
110 citations
,
August 2004 in “British Journal of Dermatology” In this study, researchers identified the ventral matrix as the primary source of nail plate formation, while the dorsal portion is generated by the apical matrix.
19 citations
,
July 1964 in “PubMed” This study observed that undifferentiated matrix cells at the base of the hair follicle differentiate into the medulla, cortex, cuticle, and inner root sheath cell types through specific morphological changes.
2 citations
,
June 2022 in “Scientific reports” This study found that women with PCOS had significantly higher hair cortisol concentrations, suggesting hyperactivation of the HPA axis may affect metabolic and inflammatory markers in those with elevated cortisol levels.
46 citations
,
October 2018 in “Neuroscience Bulletin” 2 citations
,
November 1992 in “Journal of dermatology” This study found that cells isolated from human scalp hair follicles proliferated well in a specific culture medium and possessed keratins characteristic of hair-forming cells.
42 citations
,
September 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS who have an exaggerated 17-hydroxyprogesterone response to buserelin exhibit more severe hyperandrogenemia, increased insulin secretion, and reduced insulin sensitivity.
14 citations
,
February 2011 in “Experimental dermatology” This study identifies cartilage oligomeric matrix protein (COMP) as a key extracellular matrix component in human hair follicle cycling, potentially regulated by TGFβ signaling, and suggests its importance in normal hair follicle biology.