Restricted Effects of Androgens on Glucocorticoid Signaling in the Mouse Prefrontal Cortex and Midbrain

The study explores how androgens modulate glucocorticoid signaling in the mouse brain, particularly in the prefrontal cortex and midbrain where androgen and glucocorticoid receptors are co-expressed. It reveals that androgens, such as dihydrotestosterone, and glucocorticoids, like corticosterone, inversely regulate gene expression in these areas. The androgen receptor antagonist enzalutamide reduces corticosterone-induced gene expression, indicating that androgens can modulate glucocorticoid signaling. However, glucocorticoid effects are largely resilient to androgen influence, suggesting a complex but modest interaction. The study emphasizes the need for further research with physiological hormone levels and cell-type specific effects to better understand these interactions.