Restricted Effects of Androgens on Glucocorticoid Signaling in the Mouse Prefrontal Cortex and Midbrain

    January 2024 in “ Frontiers in Endocrinology ”
    Jorge Miguel Amaya, Hetty C. M. Sips, Eva M. G. Viho … Onno C. Meijer
    Studysummary This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.
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    Research cited in this study 2

    1. Age-Dependent Regulation by Androgens of Gene Expression in the Anterior Hypothalamus and Stress-Induced Release of Adrenal Hormones in Adolescent and Adult Male Rats Journal of neuroendocrinology · 2019
    2. Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats CNS Neuroscience & Therapeutics · 2017